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Relationship Between Calcium Metabolism Parameters

机译:钙代谢参数之间的关系

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Relationship Between Calcium Metabolism Parameters Saliha YILDIZ sup1/sup, Mustafa ?ztürk sup2/sup sup1/supDepartment of Endocrinology, Van Yuzuncu Yil University sup2/supDepartment Endocrinology, Medipol University, ?stanbul INTRODUCTION: Blood calcium is under very tight control in a narrow range of 8.5-10.5 mg / dl. We aimed to investigate the factors that contributed to this control. METHODS: 464 females and 254 males aged 16-96 years were examined retrospectively. PTH, 25OH vitamin D, Ca, Mg, P and spot urine calcium, creatinine levels were examined. RESULTS: The rates were as follow; hypercalcemia 5.6%, primary hyperparathyroidism 10.4%, secondary hyperparathyroidism 40.8%, tertiary hyperparathyroidism 17.5%, normal PTH hypercalcemia 1.25%, hypocalcemia 13.5%, hypoparathyroidism 3.7%, hypovitaminosis D 77.6%, hypophosphatemia 6.4%, hyperphosphatemia 17.5%, hypomagnesemia 17.5%, hypermagnesemia 10.4%. Severe vitamin D deficiency was 37% (n: 172) in females and 20% (n: 53) in males (p 0.01). Urinary Ca and urine creatinine 25 OH vitamin D cut-off value was 10 ng / ml and it was 13ng / ml for PTH. While vitamin D was 10-20 ng / ml, urine Ca / creatinine ratio was lowest and it increased after 20 ng / ml in females and 30 ng / ml in males. There was a negative correlation with PTH as Ca decreased from 8.3 mg / dl and a positive correlation when it increased above 9.2 mg / dl. Mg correlated positively with PTH, Ca and P (p: 0.00 r: 0.23, p: 0.007 r: 0.13, p: 0.00 r: 0.21, respectively). DISCUSSION AND CONCLUSION: Mg was found to be significantly correlated with all parameters and 25 OH vitamin D was not correlated with any parameters. On the other hand, we have determined the threshold values where the parameters interact with each other.
机译:钙代谢参数之间的关系Saliha YILDIZ 1 ,Mustafa?ztürk 2 1 范·尤尊库伊尔大学内分泌科 2 伊斯坦布尔梅迪波尔大学内分泌科简介:血液钙的控制非常严格,范围为8.5-10.5 mg / dl。我们旨在调查促成这种控制的因素。方法:回顾性分析了464名女性和254名男性,年龄在16-96岁之间。检查了PTH,25OH维生素D,Ca,Mg,P和尿液中的钙,肌酐水平。结果:发生率如下;高钙血症5.6%,原发性甲状旁腺功能亢进症10.4%,继发性甲状旁腺功能亢进症40.8%,三级甲状旁腺功能亢进症17.5%,正常PTH高钙血症1.25%,低钙血症13.5%,甲状旁腺功能低下3.7%,维生素D缺乏症77.6%,低磷酸盐血症6.4%,高磷酸盐血症17.5%,低镁血症17.5%,高镁血症10.4%。女性的严重维生素D缺乏症为37%(n:172),男性为2​​0%(n:53)(p <0.01)。尿钙和尿肌酐25 OH维生素D的截断值为10 ng / ml,PTH为13ng / ml。维生素D为10-20 ng / ml时,尿钙/肌酐比最低,女性增加20 ng / ml,男性增加30 ng / ml。当Ca从8.3 mg / dl降低时,与PTH呈负相关,当钙离子浓度高于9.2 mg / dl时呈正相关。镁与PTH,Ca和P正相关(分别为p:0.00 r:0.23,p:0.007 r:0.13,p:0.00 r:0.21)。讨论与结论:发现镁与所有参数均显着相关,而25 OH维生素D与任何参数均不相关。另一方面,我们确定了参数相互影响的阈值。

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