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首页> 外文期刊>Iranian Journal of Neurology >Optic coherence tomography findings in relapsing-remitting multiple sclerosis patients of the northwest of Iran
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Optic coherence tomography findings in relapsing-remitting multiple sclerosis patients of the northwest of Iran

机译：伊朗西北部复发缓解型多发性硬化症患者的光学相干断层扫描结果

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BackgroundOptical coherence tomography (OCT) is a simple, high-resolution technique to quantify the thickness of retinal nerve fiber layer (RNFL) and macula volume, which provide an indirect measurement of axonal damage in multiple sclerosis (MS). This study aimed to evaluate OCT finding in relapsing-remitting MS patients of the northwest of Iran and compare them with a normal control group.MethodsIn a cross-sectional, descriptive, analytic study, 60 patients with MS as case group and 60 patients as controls were studied. Total macular volume (TMV) and retinal nerve fiber layer (RNFL) in perioptic disk area (3.4 millimeter around the disk) and macula was measured using Stratus 3000 in circular form. These findings were compared between the two groups and their relationship with the duration and severity of MS [based on Expanded Disability Status Scale (EDSS)] and history of optic neuritis were evaluated.ResultsIn total, 35 men and 85 women with a mean age of 34.8 years were evaluated. The mean RNFL in MS patients were 231.9 and 233.1 micrometers in right and left eyes; while they were 246.7 and 250.4 micrometers in right and left eyes of healthy subjects, respectively. This difference in thickness of RNFL in total measure and all quadrants around the optic disk and TMV between case and control groups was analytically meaningful (P = 0.001 and P = 0.001 for right and left eyes, respectively). The mean thickness of RNFL in patients with optic neuritis was significantly lower than other patients in right and left eyes (P = 0.042 and P = 0.005). There was a significant correlation between most of OCT findings and the MS disease duration and EDSS.ConclusionFindings of the present study in the northwest of Iran buttress the idea that RNFL thickness can be greatly affected by MS. Our results also indicate that this effect is associated with ON and MS duration and severity.
机译：背景技术光学相干断层扫描（OCT）是一种简单的高分辨率技术，用于量化视网膜神经纤维层（RNFL）的厚度和黄斑体积，可间接测量多发性硬化症（MS）中的轴突损伤。这项研究旨在评估伊朗西北部复发缓解型MS患者的OCT发现并将其与正常对照组进行比较。方法在一项横断面描述性分析研究中，将60例MS患者作为病例组，将60例患者作为对照被研究了。使用圆形Stratus 3000测量视盘周围（盘周围3.4毫米）和黄斑的总黄斑体积（TMV）和视网膜神经纤维层（RNFL）。比较了两组患者的这些发现，并评估了它们与MS的持续时间和严重程度之间的关系[基于扩展残疾状态量表（EDSS）]和视神经炎的病史。结果总共有35名男性和85名女性，平均年龄为评估了34.8年。 MS患者左眼和右眼的平均RNFL分别为231.9和233.1微米;健康受试者的右眼和左眼分别为246.7和250.4微米。病例组和对照组之间的总大小，视盘周围所有象限和TMV的RNFL厚度差异具有分析意义（分别为右眼和左眼P = 0.001和P = 0.001）。视神经炎患者的RNFL平均厚度显着低于其他右眼和左眼患者（P = 0.042和P = 0.005）。 OCT的大多数发现与MS病程和EDSS之间存在显着相关性。结论本研究在伊朗西北部的发现支持了MS可能极大地影响RNFL厚度。我们的结果还表明，这种影响与ON和MS的持续时间及严重程度有关。

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