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首页> 外文期刊>Iranian Journal of Neurology >Factors affecting bone mineral density in multiple sclerosis patients
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Factors affecting bone mineral density in multiple sclerosis patients

机译：影响多发性硬化症患者骨矿物质密度的因素

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BackgroundMultiple sclerosis (MS) is a demyelinating disease which can cause many disabilities for the patient. Recent data suggests that MS patients have higher risk for osteoporosis. This study was performed to investigate if the osteoporosis prevalence is higher in MS patients and to determine the possible factors affecting bone mineral density (BMD).Methods51 definite relapsing-remitting MS patients according to McDonald's criteria (45 females, 6 males aged between 20 and 50 years) participated in this study. The control group included 407 females aged from 20 to 49 years; they were healthy and had no history of the diseases affecting bone metabolism. Femoral and lumbar BMD were measured by Dual Energy X-ray Absorptiometry (DXA). The disability of MS patients was evaluated by Expanded Disability Status Scale (EDSS). The patient's quality of life was evaluated by the validated Persian version of multiple sclerosis impact scale (MSIS-29).ResultsPatients’ mean age was 36 ± 3.3 years and their mean disease duration was 8.7 ± 1.7 years. The mean EDSS score and the mean body mass index (BMI) of the patients were 3 ± 0.9 and 23.5 ± 2.3 kg/m2, respectively. 29% of the patients had never been treated by ?-interferon and 6% of them had not received glucocorticoids (GCs) pulses since their MS had been diagnosed. 26% of the patients had a history of fracture.18% of our patients were osteoporotic and 43% of them were osteopenic. Femoral BMD was significantly lower among MS patients than age matched controls (P < 0.001), but lumbar BMD showed no difference. There was no correlation between administration of GCs pulses, interferon and BMD; however, we found a significant correlation between EDSS score, quality of life (QoL), disease duration and BMD of both site.ConclusionAs a result of this study, bone loss inevitably occurs in MS patients. The major factor of BMD loss is immobility. Osteoporosis should be managed as part of MS patients’ treatment protocols.
机译：背景多发性硬化症（MS）是一种脱髓鞘疾病，可导致患者许多残疾。最新数据表明，MS患者发生骨质疏松症的风险更高。这项研究旨在调查MS患者中骨质疏松症的患病率是否较高，并确定可能影响骨矿物质密度（BMD）的因素。方法51根据麦当劳标准确定的复发缓解型MS患者（女性45例，男性20岁至20岁之间6例） 50年）参加了这项研究。对照组包括407名年龄在20至49岁之间的女性。他们很健康，没有影响骨骼代谢的疾病史。股骨和腰椎骨密度通过双能X线吸收法（DXA）测量。 MS患者的残疾通过扩展残疾状况量表（EDSS）进行评估。患者的生活质量通过经过验证的波斯语版本的多发性硬化症影响量表（MSIS-29）进行评估。结果患者的平均年龄为36±3.3岁，平均病程为8.7±1.7岁。患者的平均EDSS评分和平均体重指数（BMI）分别为3±0.9和23.5±2.3 kg / m2。自从他们的MS被诊断以来，有29％的患者从未接受过β-干扰素的治疗，其中6％没有接受糖皮质激素（GCs）脉冲治疗。 26％的患者有骨折史.18％的患者患有骨质疏松症，其中43％为骨质疏松症。 MS患者的股骨BMD明显低于年龄匹配的对照组（P <0.001），但腰部BMD没有差异。 GCs脉冲，干扰素和BMD的给药之间没有相关性。然而，我们发现EDSS评分，生活质量（QoL），疾病持续时间和两个部位的BMD之间都存在显着相关性。结论本研究的结果是，MS患者不可避免地发生骨质流失。 BMD损失的主要因素是不动。骨质疏松症应作为MS患者治疗方案的一部分进行管理。

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