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首页> 外文期刊>Iranian Journal of Microbiology >No evidence for occult HBV infection in hepatitis B vaccine non-responders.
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No evidence for occult HBV infection in hepatitis B vaccine non-responders.

机译：没有证据表明乙型肝炎疫苗无反应者隐匿性HBV感染。

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Background and Objective: Although hepatitis B vaccine immunogenicity is high, certain risk factors such as age, tobacco consumption, obesity and genetic background have been associated with low responsiveness to HBV vaccine. We aimed to evaluate the role of occult hepatitis B virus (HBV) infection in non-responder adults to HBV vaccine in a low endemic area for HBV.Material and Methods: A total of 52 subjects who were non-responder to HBV vaccine were enrolled in the study. HBsAg, anti-HBs and anti-HBc were tested in all subjects. The presence of HBV-DNA was determined in plasma samples by real- time PCR.Results: A total of 52 cases with median age 34 years were enrolled in the study. 63.5% of patients were male and 36.5% were female. Isolated anti-HBc (HBsAg negative, anti-HBs negative and anti-HBc positive) was detected in 3.8% of cases. HBV-DNA was not detected in our cases.?Conclusion: This study showed no evidence of occult HBV infection in our HBV vaccine non-responders even in cases with isolated anti-HBc.
机译：背景与目的：尽管乙型肝炎疫苗的免疫原性很高，但是某些危险因素，例如年龄，烟草消费，肥胖和遗传背景与对乙肝疫苗的低应答性有关。我们的目的是评估在乙型肝炎低流行地区对乙肝疫苗无反应的成年人中隐匿性乙型肝炎病毒（HBV）感染的作用。材料与方法：共有52名对乙肝疫苗无反应的受试者入选。在研究中。在所有受试者中均测试了HBsAg，抗HBs和抗HBc。结果：共有52例中位年龄为34岁的患者参与了该研究。血浆中存在HBV-DNA。男性占63.5％，女性占36.5％。在3.8％的病例中检出了孤立的抗HBc（HBsAg阴性，抗HBs阴性和抗HBc阳性）。结论：该研究表明，即使在分离的抗HBc病例中，我们的HBV疫苗无反应者也没有隐匿性HBV感染的证据。

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