...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Iranian Journal of Neurology >The effects of botulinum toxin type A injection on pain symptoms, quality of life, and sleep quality of patients with diabetic neuropathy: A randomized double-blind clinical trial
【24h】

The effects of botulinum toxin type A injection on pain symptoms, quality of life, and sleep quality of patients with diabetic neuropathy: A randomized double-blind clinical trial

机译：甲型肉毒杆菌毒素注射对糖尿病性神经病患者的疼痛症状，生活质量和睡眠质量的影响：一项随机双盲临床试验

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Neuropathic pain is one of the most common problems in patients with diabetes mellitus (DM). In this study, the effect of botulinum toxin type A (BTX-A) on neuropathic pain, quality of sleep, and quality of life of diabetic patients with sensorimotor polyneuropathy was studied. Methods: This randomized placebo-controlled trial study was carried out in a double-blind (patient-researcher) method. The study was performed on 32 patients with type 2 DM. Neuropathy was confirmed by Douleur Neuropathique 4 (DN4) Questionnaire and nerve conduction study (NCS). The patients were randomly assigned to two intervention and control groups based on the random numbers table. After selecting the subjects, we used 36-Item Short Form Health Survey (SF-36), Neuropathic Pain Scale (NPS), Visual Analogue Scale (VAS), and Pittsburgh Sleep Quality Index (PSQI) questionnaires before and after 3 months of 100 units BTX-A injection (as intervention group) or same amount of chloride sodium (as control group) to the subjects' feet. The data were analyzed by SPSS software using independent two-sample t-test, chi-square test, and one-way repeated measures analysis of variance (ANOVA). Results: 12 male and 20 female patients participated in this study. There was a significant difference in the mean VAS, PSQI, physical dimension of the SF-36, and some NPS indices over time (12 weeks) (P 0.001). Conclusion: The results of this study showed that BTX-A reduced neuropathic pain and improved the quality of life and sleep in people with diabetic neuropathy.
机译：背景：神经性疼痛是糖尿病（DM）患者最常见的问题之一。在这项研究中，研究了A型肉毒毒素（BTX-A）对糖尿病合并感觉运动性多发性神经病患者的神经性疼痛，睡眠质量和生活质量的影响。方法：这项随机安慰剂对照试验研究以双盲（患者研究者）方法进行。该研究针对32位2型DM患者进行。通过Douleur Neuropathique 4（DN4）问卷和神经传导研究（NCS）确认了神经病变。根据随机数表将患者随机分为两个干预组和对照组。在选择受试者之后，我们在3个月的100个月前后使用了36项简短形式健康调查（SF-36），神经性疼痛量表（NPS），视觉类比量表（VAS）和匹兹堡睡眠质量指数（PSQI）问卷。向受试者的脚注射BTX-A单位（作为干预组）或等量的氯化钠（作为对照组）。通过SPSS软件使用独立的两样本t检验，卡方检验和单向重复方差分析（ANOVA）对数据进行分析。结果：12例男性和20例女性患者参加了这项研究。随着时间的推移（12周），平均VAS，PSQI，SF-36的物理尺寸以及一些NPS指数存在显着差异（P <0.001）。结论：这项研究的结果表明，BTX-A可减轻糖尿病性神经病患者的神经性疼痛并改善其生活和睡眠质量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号