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首页> 外文期刊>EBioMedicine >Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register
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Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register

机译：精神分裂症发病年龄的早期与遗传易感性增加有关吗？全国范围的丹麦双胞胎注册数据分析

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Abstract Background Early age at illness onset has been viewed as an important liability marker for schizophrenia, which may be associated with an increased genetic vulnerability. A twin approach can be valuable, because it allows for the investigation of specific illness markers in individuals with a shared genetic background. Methods We linked nationwide registers to identify a cohort of twin pairs born in Denmark from 1951 to 2000 (N = 31,524 pairs), where one or both twins had a diagnosis in the schizophrenia spectrum. We defined two groups consisting of; N = 788 twin pairs (affected with schizophrenia spectrum) and a subsample of N = 448 (affected with schizophrenia). Survival analysis was applied to investigate the effect of age at illness onset. Findings We found that early age at illness onset compared to later onset in the first diagnosed twin can be considered a major risk factor for developing schizophrenia in the second twin. Additionally, we found that the stronger genetic component in {MZ} twins compared to {DZ} twins is manifested in the proximity of assigned diagnosis within pairs. Discussion Early onset schizophrenia could be linked to a more severe genetic predisposition, indicating that age might be perceived as a clinical marker for genetic vulnerability for the illness.
机译：摘要背景疾病发病的早年龄被认为是精神分裂症的重要责任标志，可能与遗传易感性增加有关。双胞胎方法可能是有价值的，因为它允许调查具有共同遗传背景的个体中的特定疾病标记。方法我们将全国范围内的登记册联系起来，以鉴定1951年至2000年在丹麦出生的一对双胞胎（N = 31,524对），其中一个或两个双胞胎均患有精神分裂症。我们定义了两个组： N = 788对双胞胎（受精神分裂症频谱影响）和N = 448的子样本（受精神分裂症影响）。生存分析用于研究疾病发作时年龄的影响。发现我们发现，与第一例被诊断为双胞胎的晚发病相比，发病年龄早于第二例双胞胎发展为精神分裂症的主要危险因素。此外，我们发现{MZ}双胞胎比{DZ}双胞胎更强的遗传成分表现在成对的指定诊断附近。讨论精神分裂症的早期发作可能与更严重的遗传易感性有关，这表明年龄可能被视为该疾病遗传易感性的临床标志。

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