• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>EBioMedicine >Follicular Helper T Cells are Essential for the Elimination of Plasmodium Infection
【24h】

Follicular Helper T Cells are Essential for the Elimination of Plasmodium Infection

机译：滤泡辅助性T细胞对于消除疟原虫感染至关重要

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

CD4^+ follicular helper T (Tfh) cells have been shown to be critical for the activation of germinal center (GC) B-cell responses. Similar to other infections, Plasmodium infection activates both GC as well as non-GC B cell responses. Here, we sought to explore whether Tfh cells and GC B cells are required to eliminate a Plasmodium infection. A CD4 T cell-targeted deletion of the gene that encodes Bcl6, the master transcription factor for the Tfh program, resulted in complete disruption of the Tfh response to Plasmodium chabaudi in C57BL/6 mice and consequent disruption of GC responses and IgG responses and the inability to eliminate the otherwise self-resolving chronic P. chabaudi infection. On the other hand, and contrary to previous observations in immunization and viral infection models, Signaling Lymphocyte Activation Molecule (SLAM)-Associated Protein (SAP)-deficient mice were able to activate Tfh cells, GC B cells, and IgG responses to the parasite. This study demonstrates the critical role for Tfh cells in controlling this systemic infection, and highlights differences in the signals required to activate GC B cell responses to this complex parasite compared with those of protein immunizations and viral infections. Therefore, these data are highly pertinent for designing malaria vaccines able to activate broadly protective B-cell responses.
机译：已经证明CD4 +滤泡辅助性T（Tfh）细胞对于生发中心（GC）B细胞应答的激活至关重要。与其他感染相似，疟原虫感染会激活GC和非GC B细胞反应。在这里，我们试图探讨是否需要Tfh细胞和GC B细胞来消除疟原虫感染。以CD4 T细胞为靶点的编码Bcl6（Tfh程序的主要转录因子）的基因的缺失导致C57BL / 6小鼠对Chabaudi疟原虫的Tfh反应完全被破坏，进而导致GC反应和IgG反应以及无法消除原本可以自行解决的慢性沙巴氏假单胞菌感染。另一方面，与先前在免疫和病毒感染模型中的观察结果相反，信号淋巴细胞活化分子（SLAM）-相关蛋白（SAP）缺陷小鼠能够激活Tfh细胞，GC B细胞和IgG对寄生虫的反应。这项研究证明了Tfh细胞在控制这种全身性感染中的关键作用，并强调了与蛋白质免疫和病毒感染相比，激活GC B细胞对这种复杂寄生虫的反应所需的信号差异。因此，这些数据与设计能够激活广泛保护性B细胞反应的疟疾疫苗高度相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号