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首页> 外文期刊>EBioMedicine >Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission
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Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission

机译：心胸移植受者人支原体：可能的供体传播的罕见感染。

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Abstract The role of infection with Mycoplasma hominis following cardiothoracic organ transplantation and its source of transmission have not been well-defined. Here, we identify and describe infection with M. hominis in patients following cardiothoracic organ transplantation after reviewing all cardiothoracic transplantations performed at our center between 1998 and July 2015. We found seven previously unreported cases of M. hominis culture positive infection all of whom presented with pleuritis, surgical site infection, and/or mediastinitis. {PCR} was used to establish the diagnosis in four cases. In two instances, paired single lung transplant recipients manifested infection, and in one of these pairs, isolates were indistinguishable by multilocus sequence typing (MLST). To investigate the prevalence of M. hominis in the lower respiratory tract, we tested 178 bronchoalveolar lavage (BAL) fluids collected from immunocompromised subjects for M. hominis by PCR; all were negative. Review of the literature revealed an additional 15 cases of M. hominis in lung transplant recipients, most with similar clinical presentations to our cases. We recommend that M. hominis should be considered in post-cardiothoracic transplant infections presenting with pleuritis, surgical site infection, or mediastinitis. M. hominis {PCR} may facilitate early diagnosis and prompt therapy. Evaluation for possible donor transmission should be considered.
机译：摘要心胸器官移植后人型支原体感染的作用及其传播来源尚未明确。在这里，我们回顾并回顾了我们中心在1998年至2015年7月之间进行的所有心胸移植手术后，确定并描述了心胸器官移植术后人型支原体感染。我们发现了7例以前未报告的人型支原体培养阳性感染病例，所有这些病例均表现为胸膜炎，手术部位感染和/或纵隔炎。 {PCR}用于诊断4例。在两个实例中，成对的单肺移植受者表现出感染，而在其中一对中，分离株通过多基因座序列分型（MLST）无法区分。为了研究人呼吸道杆菌的下呼吸道患病率，我们通过PCR检测了从免疫力低下的受试者收集的178支支气管肺泡灌洗液（BAL）;一切都是负面的。文献回顾显示，在肺移植受者中还有15例人型支原体，大多数与我们的病例具有相似的临床表现。我们建议在伴有胸膜炎，手术部位感染或纵隔炎的心胸大肠移植术后感染中考虑人型支原体。人型支原体{PCR}可能有助于早期诊断和及时治疗。应考虑对可能的捐助者传播的评估。

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