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首页> 外文期刊>EBioMedicine >Paracetamol Medication During Pregnancy: Insights on Intake Frequencies, Dosages and Effects on Hematopoietic Stem Cell Populations in Cord Blood From a Longitudinal Prospective Pregnancy Cohort
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Paracetamol Medication During Pregnancy: Insights on Intake Frequencies, Dosages and Effects on Hematopoietic Stem Cell Populations in Cord Blood From a Longitudinal Prospective Pregnancy Cohort

机译：妊娠期间使用扑热息痛的药物：纵向预期妊娠队列中脐带血摄入频率，剂量及对造血干细胞群的影响

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Background Paracetamol is the first choice for antipyretic or analgesic treatment throughout pregnancy. Products with Paracetamol are readily available over the counter and therefore easily accessible for self-medication. Epidemiological data on Paracetamol intake pattern during pregnancy and its potential immunological effects are sparse. We aimed to analyze a possible association between Paracetamol medication and numbers of hematopoietic stem cells (HSC) in cord blood. Methods The objective was addressed in the PRINCE ( PR ENATAL DETERM IN ANTS OF C HILDREN'S H E ALTH) study, a population-based prospective pregnancy cohort study initiated in 2011 at the University Medical Center in Hamburg, Germany. 518 healthy pregnant women with singleton pregnancies were recruited during the first trimester. Three examinations were scheduled at the end of the 1st (gestational week 12–14), the 2nd (gestational week 22–24) and the 3rd trimester (gestational week 34–36). For 146 of these women, cord blood flow cytometry data were available. Paracetamol intake was assessed for each trimester of pregnancy. Findings Among the 518 enrolled women, 40% took Paracetamol as main analgesic treatment during pregnancy. The intake frequency and dosage of Paracetamol varied between the women and was overall low with a tendency towards higher frequencies and higher dosages in the third trimester. Paracetamol intake, particularly during the third trimester, resulted in decreased relative numbers of HSCs in cord blood, independent of maternal age, first-trimester BMI, parity, gestational age and birth weight (? 0.286 (95% CI ? 0.592, 0.021), p = 0.068). Interpretation Prenatal Paracetamol intake, especially during the third trimester, may be causally involved in decreasing HSCs in cord blood.
机译：背景扑热息痛是整个妊娠期间进行退烧或止痛治疗的首选。带有扑热息痛的产品很容易在柜台上买到，因此很容易自我治疗。怀孕期间扑热息痛摄入量的流行病学数据及其潜在的免疫学影响稀疏。我们旨在分析扑热息痛药物与脐带血中造血干细胞（HSC）数量之间的可能关联。方法该目标在2011年在德国汉堡大学医学中心进行的一项基于人群的前瞻性队列研究中进行了PRINCE（儿童肛门疾病的PR决定）研究。在头三个月中招募了518名单胎妊娠的健康孕妇。在第一个（妊娠第12-14周），第二个（妊娠第22-24周）和第三个中期（妊娠第34-36周）结束时安排了三项检查。对于这些妇女中的146名，可获得脐带血流式细胞仪数据。在妊娠的每三个月评估扑热息痛的摄入量。调查结果在518名登记女性中，有40％在怀孕期间服用扑热息痛作为主要镇痛药。扑热息痛的摄入频率和剂量在女性之间有所不同，总体偏低，在孕晚期有较高的频率和较高的剂量。扑热息痛的摄入，特别是在孕晚期，导致脐血中HSC的相对数量减少，而与产妇年龄，孕早期的BMI，胎次，胎龄和出生体重无关（？0.286（95％CI？0.592，0.021）， p = 0.068）。解释产前扑热息痛的摄入，尤其是在孕晚期，可能与脐血中HSC的降低有关。

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