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首页> 外文期刊>EBioMedicine >Association Between Twelve Polymorphisms in Five X-ray Repair Cross-complementing Genes and the Risk of Urological Neoplasms: A Systematic Review and Meta-Analysis
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Association Between Twelve Polymorphisms in Five X-ray Repair Cross-complementing Genes and the Risk of Urological Neoplasms: A Systematic Review and Meta-Analysis

机译：五个X射线修复交叉互补基因中的十二个多态性与泌尿系统肿瘤风险之间的关联：系统评价和荟萃分析

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Highlights ? Polymorphisms in XRCC genes have been reported to have potential links with the risk of urological neoplasms. ? XRCC1 -rs25489 polymorphism is a risk factor for urological neoplasms, particularly for bladder cancer. ? XRCC1 -rs25487 polymorphism is a risk factor particularly for urological neoplasms in Asian population. Genetic factors play a crucial role in urological neoplasms risk. Polymorphisms in XRCC genes were associated with occurrence or increase of various tumors. But the effects of XRCC genes on urological neoplasms were unclear. Our results identified that XRCC1 -rs25489 polymorphism is a risk factor for urological neoplasms, particularly for bladder cancer, while XRCC1 -rs25487 polymorphism is a risk factor for urological neoplasms restricted to Asians. By using these variations as biomarkers, it is more feasible to estimate the risk of acquiring urological neoplasms and thus formulate timely preventive strategy. Polymorphisms in X-ray repair cross-complementing ( XRCC ) genes have been implicated in altering the risk of various urological cancers. However, the results of reported studies are controversial. To ascertain whether polymorphisms in XRCC genes are associated with the risk of urological neoplasms, we conducted present updated meta-analysis and systematic review. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to estimate the association. Finally, 54 publications comprising 129 case-control studies for twelve polymorphisms in five XRCC genes were enrolled. We identified that XRCC1 -rs25489 polymorphism was associated with an increased risk of urological neoplasms in heterozygote and dominant models. Moreover, in the subgroup analysis by cancer type, we found that XRCC1 -rs25489 polymorphism was associated with an increased risk of bladder cancer (BC) in heterozygote model. Although overall analyses suggested a null result for XRCC1 -rs25487 polymorphism, in the stratified analysis by ethnicity, an increased risk of urological neoplasms for Asians in allelic and homozygote models was identified. While for other polymorphisms in XRCC genes, no significant association was uncovered. To sum up, our results indicated that XRCC1 -rs25489 polymorphism is a risk factor for urological neoplasms, particularly for BC. Further studies with large sample size are needed to validate these findings.
机译：强调 ？据报道，XRCC基因的多态性与泌尿系肿瘤的风险具有潜在的联系。 ？ XRCC1-rs25489多态性是泌尿系肿瘤（尤其是膀胱癌）的危险因素。 ？ XRCC1-rs25487基因多态性是一个危险因素，特别是对于亚洲人群中的泌尿科肿瘤。遗传因素在泌尿科肿瘤风险中起关键作用。 XRCC基因的多态性与各种肿瘤的发生或增加有关。但尚不清楚XRCC基因对泌尿系统肿瘤的影响。我们的研究结果表明，XRCC1-rs25489多态性是泌尿系统肿瘤的危险因素，特别是对于膀胱癌，而XRCC1-rs25487多态性是限于亚洲人的泌尿系统肿瘤的危险因素。通过使用这些变异作为生物标志物，估计获得泌尿科肿瘤的风险，从而制定及时的预防策略是更可行的。 X射线修复交叉互补（XRCC）基因中的多态性与改变各种泌尿系统癌症的风险有关。但是，报道的研究结果存在争议。为了确定XRCC基因中的多态性是否与泌尿系统肿瘤的风险相关，我们进行了最新的荟萃分析和系统评价。摘要比值比（OR）和相应的95％置信区间（CI）用于估计关联。最后，纳入了包括129个病例对照研究在内的54个出版物，这些研究涉及五个XRCC基因中的十二个多态性。我们确定XRCC1-rs25489多态性与杂合子和优势模型中泌尿外科肿瘤的风险增加有关。此外，在按癌症类型进行的亚组分析中，我们发现XRCC1-rs25489多态性与杂合子模型中膀胱癌（BC）的风险增加有关。尽管总体分析显示XRCC1-rs25487多态性没有结果，但在按种族进行的分层分析中，确定了在等位基因和纯合子模型中亚洲人泌尿外科肿瘤的风险增加。对于XRCC基因中的其他多态性，未发现显着关联。综上所述，我们的结果表明XRCC1-rs25489多态性是泌尿系肿瘤，尤其是BC的危险因素。需要进一步的大样本研究以验证这些发现。

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