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Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis

机译：继发性多发性硬化症中铝和硅的尿排泄

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Background Progressive multiple sclerosis is a chronic autoimmune condition of unknown aetiology and few therapeutic options. Human exposure to aluminium has been linked with multiple sclerosis and affected individuals are known to excrete unusually high amounts of aluminium in their urine. Silicon-rich mineral waters facilitate the removal of aluminium from the body in urine and herein we have tested their efficacy in affecting urinary excretion of aluminium in individuals diagnosed with secondary progressive multiple sclerosis (SPMS). Methods Urinary excretion of aluminium and silicon, measured using transversely-heated graphite furnace atomic absorption spectrometry, was determined in 15 individuals diagnosed with SPMS over 24 weeks, a 12 week baseline period (control) followed by a 12 week treatment period, during which individuals consumed up to 1.5 L of a silicon-rich mineral water every day. Findings Individuals with SPMS excreted high amounts of aluminium during the baseline period (135.2 nmol/mmol Crt (70.3–222.2, n = 180) and females excreted significantly more aluminium than males. Regular drinking of a silicon-rich mineral water increased the urinary excretion of aluminium significantly (349.0 nmol/mmol Crt (231.7–524.7, n = 180; three-way ANOVA, F1,13 = 59.17, p-value = 0.000003) relative to the baseline period. The majority of individuals, 14 out of 15, excreted more aluminium (μmol/24 h) following drinking of a silicon-rich mineral water (independent-test, p.
机译：背景进行性多发性硬化症是一种病因不明，治疗选择很少的慢性自身免疫病。人体暴露于铝与多发性硬化症有关，并且已知受影响的人尿中排泄异常大量的铝。富含硅的矿泉水有助于从人体尿液中去除铝，在此我们已经测试了它们在诊断为继发性进行性多发性硬化症（SPMS）的个体中影响尿铝排泄的功效。方法用横向加热的石墨炉原子吸收光谱法测定的15名经SPMS诊断为24周，基线期（对照）为12周，随后为12周的治疗期的个体中的铝和硅的尿排泄量。每天消耗多达1.5升的富含硅的矿泉水。结果在基线期，患有SPMS的人排泄了大量的铝（135.2 nmol / mmol Crt（70.3–222.2，n = 180），女性排泄的铝明显多于男性，经常喝富含硅的矿泉水会增加尿液的排泄。相对于基线期的铝含量（349.0 nmol / mmol Crt（231.7–524.7，n = 180;三效方差分析，F <1,13 = 59.17，p值= 0.000003））。喝富含硅的矿泉水后，大多数人（15人中有14个人）会排泄更多的铝（μmol/ 24小时）（独立测试，第7页）。

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