• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>EBioMedicine >IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)
【24h】

IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)

机译：IgM抗丙二醛低密度脂蛋白抗体水平在北欧地尔硫卓（NORDIL）研究和综合成像与生物标志物研究3（IBIS-3）中表明了冠心病和坏死核心特征

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Certain immunoglobulins (Ig) are proposed to have protective functions in atherosclerosis. Objectives We tested whether serum levels of IgG and IgM autoantibodies against malondialdehyde low density lipoprotein (MDA-LDL) are associated with clinical coronary heart disease (CHD) and unfavorable plaque characteristics. Methods NORDIL was a prospective study investigating adverse cardiovascular outcomes in hypertensive patients. IBIS-3 analyzed lesions in a non-culprit coronary artery with Findings From 10,881 NORDIL patients, 87 had serum sampled at baseline and developed CHD over 4.5?years, matched to 227 controls. Higher titers of IgM anti-MDA-LDL had a protective effect on adverse outcomes, with odds ratio 0.29 (0.11, 0.76; p?=?0.012; p?=?0.016 for trend). Therefore, the effect was explored at the lesional level in IBIS-3. 143 patients had blood samples and RF-IVUS measurements available, and NIRS was performed in 90 of these. At baseline, IgM anti-MDA-LDL levels had a strong independent inverse relationship with lesional necrotic core volume (p?=?0.027) and percentage of plaque occupied by necrotic core (p?=?0.011), as well as lipid core burden index (p?=?0.024) in the worst 4?mm segment. Interpretation Our study supports the hypothesis that lower circulating levels of IgM anti-MDA-LDL are associated with clinical CHD development, and for the first time relates these findings to atherosclerotic plaque characteristics that are linked to vulnerability.
机译：背景技术某些免疫球蛋白（Ig）被提议在动脉粥样硬化中具有保护功能。目的我们测试了针对丙二醛低密度脂蛋白（MDA-LDL）的IgG和IgM自身抗体的血清水平是否与临床冠心病（CHD）和不良斑块特征相关。方法NORDIL是一项前瞻性研究，旨在研究高血压患者的不良心血管预后。 IBIS-3分析了非罪犯冠状动脉中的病变，发现10,881名NORDIL患者中，有87名在基线时进行了血清采样，并在4.5年内发展为CHD，与227名对照相匹配。较高效价的IgM抗MDA-LDL对不良结局具有保护作用，比值比为0.29（趋势为0.11，0.76; p <= 0.012; p == 0.016）。因此，在IBIS-3的病变水平探讨了这种作用。 143例患者有血液样本并可以进行RF-IVUS测量，其中90例患者进行了NIRS。在基线时，IgM抗MDA-LDL水平与病变坏死核心体积（p？=？0.027）和坏死核心所占的斑块百分比（p？=？0.011）以及脂质核心负荷有很强的独立反比关系。最差4？mm段中的指数（p？=？0.024）。解释我们的研究支持以下假说：IgM抗MDA-LDL的循环水平降低与临床冠心病的发展有关，并且首次将这些发现与动脉粥样硬化斑块特征相关联，而动脉粥样硬化斑块特征与脆弱性有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号