...
首页> 外文期刊>EBioMedicine >Lighting a Fire in the Tumor Microenvironment Using Oncolytic Immunotherapy
【24h】

Lighting a Fire in the Tumor Microenvironment Using Oncolytic Immunotherapy

机译:使用溶瘤免疫疗法在肿瘤微环境中点火

获取原文
           

摘要

Oncolytic virus (OV) therapy is potentially a game-changing cancer treatment that has garnered significant interest due to its versatility and multi-modal approaches towards tumor eradication. In the field of cancer immunotherapy, the immunological phenotype of the tumor microenvironment (TME) is an important determinant of disease prognosis and therapeutic success. There is accumulating data that OVs are capable of dramatically altering the TME immune landscape, leading to improved antitumor activity alone or in combination with assorted immune modulators. Herein, we review how OVs disrupt the immunosuppressive TME and can be used strategically to create a “pro-immune” microenvironment that enables and promotes potent, long-lasting host antitumor immune responses.
机译:溶瘤病毒(OV)治疗具有潜在的变革性的癌症治疗方法,由于其多功能性和根除肿瘤的多模式方法,已经引起了广泛的关注。在癌症免疫治疗领域,肿瘤微环境(TME)的免疫表型是疾病预后和治疗成功的重要决定因素。越来越多的数据表明,OVs能够显着改变TME的免疫状况,从而单独或与各种免疫调节剂组合使用都能提高抗肿瘤活性。在本文中,我们回顾了OVs如何破坏免疫抑制性TME,并可以策略性地用于创建“促免疫”微环境,从而实现并促进有效,持久的宿主抗肿瘤免疫反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号