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首页> 外文期刊>EBioMedicine >Is the delivery mode a critical factor for the microbial communities in the meconium?
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Is the delivery mode a critical factor for the microbial communities in the meconium?

机译：分娩方式是否对粪便中的微生物群落至关重要？

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Background Mothers are the primary source of bacteria for newborns, but it is unclear whether mother-to-newborn transmission occurs prior to, during or after birth. Similarly, the effect of the delivery mode on neonatal microorganisms has been the focus of controversy. Methods Healthy maternal and neonatal pairs that underwent vaginal birth and caesarean section were enrolled in this study. Meconium, placenta, membrane and amniotic fluid samples for newborns and vaginal, rectal and oral samples for mothers were collected. All samples were amplified and sequenced by a 16S rRNA gene primer set targeting bacteria and archaea. Findings A total of 550 samples from 36 mother-neonate pairs with vaginal births and 42 mother-neonate pairs with caesarean sections were included in this study. The negative controls showed that the data analysis in this study was not affected by contamination. There was a high diversity of microbial communities in the pregnancy environment of the foetus. Meconium samples could be divided into three distinct types that were not influenced by the delivery method. Interpretation The distribution patterns of bacterial communities in the meconium, placenta, and foetal membranes were highly similar and had nothing to do with the mode of delivery. For approximately half of the placental microorganisms, the same sequence could be found in the vaginal, rectal, and oral samples of the mother.
机译：背景技术母亲是新生儿的主要细菌来源，但目前尚不清楚母亲到新生儿的传播是否发生在出生之前，期间或之后。同样，递送方式对新生儿微生物的影响一直是争议的焦点。方法选择健康的经阴道分娩和剖腹产的母婴配对。收集新生儿的胎粪，胎盘，胎膜和羊水样本，母亲的阴道，直肠和口腔样本。所有样品均通过针对细菌和古细菌的16S rRNA基因引物组进行扩增和测序。研究结果本研究共包括36对阴道分娩的新生儿对和剖宫产的42对新生儿对的550个样本。阴性对照表明该研究中的数据分析不受污染的影响。胎儿的怀孕环境中微生物群落的多样性很高。胎粪样品可分为三种不受递送方法影响的样品。解释胎粪，胎盘和胎膜中细菌群落的分布模式非常相似，与分娩方式无关。对于大约一半的胎盘微生物，在母亲的阴道，直肠和口腔样本中可以发现相同的序列。

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