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首页> 外文期刊>EBioMedicine >Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon device
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Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon device

机译：用袖囊气球模拟胃旁路对葡萄糖代谢和非酒精性脂肪肝的影响

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Background Gastric bypass surgery is a very effective treatment of obesity and type 2 diabetes. However, very few eligible patients are offered surgery. Some patients also prefer less invasive approaches. We aimed to study the effects of the Sleeveballoon – a new device combining an intragastric balloon with a connecting sleeve, which covers the duodenal and proximal jejunal mucosa – on insulin sensitivity, glycemic control, body weight and body fat distribution. Methods We compared the effects of Sleeveballoon, Roux-en-Y Gastric-Bypass (RYGB) and sham-operation in 30 high-fat diet (HFD) fed Wistar rats. Whole body and hepatic insulin sensitivity and insulin signaling were studied. Transthoracic echocardiography was performed using a Vevo 2100 system (FUJIFILM VisualSonics Inc., Canada). Gastric emptying was measured using gastrografin. Findings Hepatic ( P ?=?.023) and whole-body ( P ?=?.011) insulin sensitivity improved in the Sleeveballoon and RYGB groups compared with sham-operated rats. Body weight reduced in both Sleeveballoon and RYGB groups in comparison to the sham-operated group (503.1?±?8.9 vs. 614.4?±?20.6?g, P ?=?.006 and 490.0?±?17.7 vs. 614.4?±?20.6?g, P?=?.006, respectively). Ectopic fat deposition was drastically reduced while glycogen content was increased in both liver and skeletal muscle. Gastric emptying (Tsub1/2/sub) was longer (157.7?±?29.2?min, P ?=?.007) in the Sleeveballoon than in sham-operated rats (97.1?±?26.3?min), but shorter in RYGB (3.5?±?1.1?min, P ??.0001). Cardiac function was better in Sleeveballoon and RYGB versus sham-operated rats. Interpretation The Sleeveballoon reduces peripheral and hepatic insulin resistance, glycaemia, body weight and ectopic fat deposition to a similar level as RYGB, although the contribution of gastric emptying to blood glucose reduction is different.
机译：背景技术胃旁路手术是肥胖和2型糖尿病的非常有效的治疗方法。但是，很少有合格的患者接受手术治疗。一些患者还喜欢侵入性较小的方法。我们旨在研究Sleeveballoon（一种将胃内气球与连接套相结合的新装置，该装置覆盖十二指肠和空肠近端黏膜）对胰岛素敏感性，血糖控制，体重和体脂分布的影响。方法我们比较了30只高脂饮食（HFD）喂养的Wistar大鼠的袖套气球，Roux-en-Y胃绕道（RYGB）和假手术的效果。研究了全身和肝胰岛素敏感性和胰岛素信号传导。经胸超声心动图使用Vevo 2100系统（加拿大FUJIFILM VisualSonics Inc.）进行。使用胃移植素测量胃排空。结果与假手术大鼠相比，在袖囊和RYGB组中，肝脏（P = 0.02）和全身（P = 0.011）胰岛素敏感性得到改善。与假手术组相比，袖套气球组和RYGB组的体重均降低（503.1±±8.9 vs. 614.4±±20.6μg，P≥0.9006，49±0.01±17.7 vs. 614.4±±。分别为20.6μg，P ＝ 0.006。在肝脏和骨骼肌中，异位脂肪沉积都大大减少，而糖原含量却增加了。与假手术大鼠相比，袖套气球中的胃排空时间（T 1/2 ）更长（157.7？±？29.2？min，P？= ?. 007）（97.1？±？26.3？min） ），但在RYGB中则更短（3.5？±？1.1？min，P？

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