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Clinical Benefit of Islet Xenotransplantation for the Treatment of Type 1 Diabetes

机译：胰岛异种移植治疗1型糖尿病的临床益处

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Background: Allogeneic islet transplantation has become a viable option for the treatment of unstable type 1 diabetes. However, the donor shortage and the necessity of the immunosuppressive drugs are two major issues. To solve these issues, we performed islet xenotransplantation using encapsulated neonatal porcine islets without immunosuppressive drugs. Methods: Two different doses (approximately 5000IEQ/kg and 10,000IEQ/kg) of encapsulated neonatal porcine islets were transplanted twice (total approximately 10,000IEQ/kg and 20,000IEQ/kg) into four type 1 diabetic patients in each group (total 8 patients). Findings: In the higher dose group, all four patients improved HbA1c. This was maintained at a level of 600days with significant reduction of the frequency of unaware hypoglycemic events. Interpretation: The clinical benefit of islet xenotransplantation with microencapsulation has been shown.
机译：背景：同种异体胰岛移植已成为治疗不稳定的1型糖尿病的可行选择。然而，供体短缺和免疫抑制药物的必要性是两个主要问题。为了解决这些问题，我们使用封装的新生猪胰岛进行了胰岛异种移植，而没有免疫抑制药物。方法：将两种不同剂量（分别为5000IEQ / kg和10,000IEQ / kg）的封装的新生猪胰岛移植两次（总计约10,000IEQ / kg和20,000IEQ / kg）到每组四名1型糖尿病患者中（共8名患者） ）。结果：在较高剂量组中，所有四名患者的HbA1c均得到改善。维持在600天的水平，无意识降血糖事件的发生频率显着降低。解释：胰岛异种移植与微囊化的临床益处已显示。

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