The Rate of Prescribing Gastrointestinal Prophylaxis with Either a Proton Pump Inhibitor Or an H2-Receptor Antagonist in Nova Scotia Seniors Starting Nonsteroidal Anti-Inflammatory Drug Therapy

Superceanu Bogdan; van Zanten Sander Veldhuyzen; Skedgel Chris; Shepherd Michael; Sketris Ingrid

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The Rate of Prescribing Gastrointestinal Prophylaxis with Either a Proton Pump Inhibitor Or an H2-Receptor Antagonist in Nova Scotia Seniors Starting Nonsteroidal Anti-Inflammatory Drug Therapy

机译：在开始非甾体类抗炎药治疗的新斯科舍省老年人中，使用质子泵抑制剂或H2受体拮抗剂规定胃肠道预防的比率

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BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used agents that can cause serious gastrointestinal (GI) side effects. For patients at increased risk of NSAID-related GI complications, prophylaxis with either a nonselective NSAID plus gastroprotective agent (GPA) or, alternatively, therapy with a cyclooxygenase-2 selective inhibitor with or without a GPA such as a proton pump inhibitor (PPI), is recommended.

机译：背景技术非甾体抗炎药（NSAID）是可以引起严重胃肠道（GI）副作用的广泛使用的药物。对于非甾体抗炎药相关胃肠道并发症风险增加的患者，可采用非选择性非甾体抗炎药加胃保护剂（GPA）进行预防，或者选择加或不加GPA的环加氧酶2选择性抑制剂（如质子泵抑制剂）进行预防，被推荐。

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《ISRN Hypertension》 |2010年第8期|共8页
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Superceanu Bogdan; van Zanten Sander Veldhuyzen; Skedgel Chris; Shepherd Michael; Sketris Ingrid;
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1. The rate of prescribing gastrointestinal prophylaxis with either a proton pump inhibitor or an H2-receptor antagonist in Nova Scotia seniors starting nonsteroidal anti-inflammatory drug therapy. [J] . Superceanu B, Veldhuyzen van Zanten S, Skedgel C, Canadian journal of gastroenterology . 2010,第8期

机译：在开始非甾体类抗炎药治疗的新斯科舍省老年人中，使用质子泵抑制剂或H2受体拮抗剂规定胃肠道预防的比率。
2. Meta-analysis: cyclooxygenase-2 inhibitors are no better than nonselective nonsteroidal anti-inflammatory drugs with proton pump inhibitors in regard to gastrointestinal adverse events in osteoarthritis and rheumatoid arthritis. [J] . Wang X, Tian HJ, Yang HK, European journal of gastroenterology and hepatology . 2011,第10期

机译：荟萃分析：就骨关节炎和类风湿关节炎的胃肠道不良反应而言，环氧合酶2抑制剂的疗效不及非选择性非甾体抗炎药和质子泵抑制剂。
3. A cluster randomized trial to measure the impact on nonsteroidal anti-inflammatory drug and proton pump inhibitor prescribing in Italy of distributing cost-free paracetamol to osteoarthritic patients [J] . Massimo Vicentini, Pamela Mancuso, Paolo Giorgi Rossi, BMC Family Practice . 2019,第1期

机译：群体随机试验，以测量意大利对非甾体抗炎药物和质子泵抑制剂对骨关节炎患者分发无价值的扑热息痛的非甾体类抗炎药物和质子泵抑制剂的影响
4. The rate of prescribing gastrointestinal prophylaxis with either a proton pump inhibitor or an H2-receptor antagonist in Nova Scotia seniors starting nonsteroidal anti-inflammatory drug therapy [O] . Bogdan Superceanu, Sander Veldhuyzen van Zanten, Chris Skedgel, 2010

机译：开始使用非甾体类抗炎药治疗的新斯科舍省老年人中质子泵抑制剂或H2受体拮抗剂处方胃肠道预防的比率
5. The rate of prescribing gastrointestinal prophylaxis with either a proton pump inhibitor or an H2-receptor antagonist in Nova Scotia seniors starting nonsteroidal anti-inflammatory drug therapy [O] . Superceanu, Bogdan, van Zanten, Sander Veldhuyzen, Skedgel, Chris, 2010

机译：在开始非甾体类抗炎药治疗的新斯科舍省老年人中，使用质子泵抑制剂或H2受体拮抗剂处方胃肠道预防的比率

The Rate of Prescribing Gastrointestinal Prophylaxis with Either a Proton Pump Inhibitor Or an H2-Receptor Antagonist in Nova Scotia Seniors Starting Nonsteroidal Anti-Inflammatory Drug Therapy

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