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An Update on the Management of Chronic Hepatitis C: 2015 Consensus Guidelines from the Canadian Association for the Study of the Liver

机译：慢性丙型肝炎的管理更新：加拿大肝病研究协会的2015年共识指南

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Chronic hepatitis C remains a significant medical and economic burden in Canada, affecting nearly 1% of the population. Since the last Canadian consensus conference on the management of chronic hepatitis C, major advances have occurred that warrant a review of recommended management approaches for these patients. Specifically, direct-acting antiviral agents with dramatically improved rates of virological clearance compared with standard therapy have been developed and interferon-free, all-oral antiviral regimens have been approved. In light of this new evidence, an update to the 2012 Canadian Association for the Study of the Liver consensus guidelines on the management of hepatitis C was produced. The present document reviews the epidemiology of hepatitis C in Canada, preferred diagnostic testing approaches and recommendations for the treatment of chronically infected patients with the newly approved antiviral agents, including those who have previously failed peginterferon and ribavirin-based therapy. In addition, recommendations are made regarding approaches to reducing the burden of hepatitis C in Canada.
机译：在加拿大，慢性丙型肝炎仍然是巨大的医疗和经济负担，影响了近1％的人口。自上届加拿大慢性丙型肝炎治疗共识会议以来，已经取得了重大进展，需要对这些患者的推荐治疗方法进行审查。特别是，已经开发出与标准疗法相比具有显着提高的病毒清除率的直接作用抗病毒药，并且已批准了无干扰素的全口服抗病毒方案。根据这一新证据，编制了《 2012年加拿大丙型肝炎研究肝脏协会共识指南》的更新。本文件回顾了加拿大丙型肝炎的流行病学，首选的诊断测试方法以及使用新批准的抗病毒药物治疗慢性感染患者的建议，包括先前接受过聚乙二醇干扰素和利巴韦林治疗失败的患者。此外，针对减轻加拿大丙型肝炎负担的方法提出了建议。

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