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Felid Herpesvirus Type 1 Infection in Cats: A Natural Host Model for Alphaherpesvirus Pathogenesis

机译:猫猫疱疹病毒1型感染:阿尔法疱疹病毒发病机理的自然宿主模型。

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Feline herpesvirus 1 (FeHV-1) is an alphaherpesvirus that causes feline viral rhinotracheitis, an important viral disease of cats on a worldwide basis. Acute FeHV-1 infection is associated with both upper respiratory and ocular signs. Following the acute phase of the disease lifelong latency is established, primarily in sensory neuronal cells. As is the case with human herpes simplex viruses, latency reactivation can result in recrudescence, which can manifest itself in the form of serious ocular lesions. FeHV-1 infection in cats is a natural host model that is useful for the identification of viral virulence genes that play a role in replication at the mucosal portals of entry or are mediators of the establishment, maintenance, or reactivation of latency. It is also a model system for defining innate and adaptive immunity mechanisms and for immunization strategies that can lead to better protection against this and other alphaherpesvirus infections.
机译:猫疱疹病毒1(FeHV-1)是一种α疱疹病毒,可引起猫病毒性鼻气管炎,这是全球范围内重要的猫病毒性疾病。急性FeHV-1感染与上呼吸道和眼部症状均相关。在疾病的急性期之后,建立了主要在感觉神经元细胞中的终身潜伏期。与人类单纯疱疹病毒一样,潜伏期重新激活可能导致复发,这种复发可能以严重的眼部损伤形式表现出来。猫中的FeHV-1感染是一种天然宿主模型,可用于鉴定病毒毒性基因,该基因在进入的粘膜入口处复制中起作用或是潜伏期的建立,维持或重新激活的介质。它也是定义先天性和适应性免疫机制以及免疫策略的模型系统,可以更好地保护这种和其他α疱疹病毒感染。

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