• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Iranian Journal of Neurology >The comparison of anti-seizure and tocolytic effects of phenytoin and magnesium sulphate in the treatment of eclampsia and preeclampsia: A randomised clinical trial
【24h】

The comparison of anti-seizure and tocolytic effects of phenytoin and magnesium sulphate in the treatment of eclampsia and preeclampsia: A randomised clinical trial

机译：苯妥英钠和硫酸镁治疗子痫和先兆子痫的抗癫痫发作和溶宫作用的比较：一项随机临床试验

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: To date, magnesium sulphate (MgSO4) is the treatment of choice for prevention of seizure in eclampsia and preeclampsia. However, there are some limitations in the administration of MgSO4 due to its tocolytic effects. The aim of this study was to compare the anticonvulsant and tocolytic effects of MgSO4 and another drug, phenytoin, in patients with eclampsia and preeclampsia.Methods: This clinical trial was conducted on pregnant women hospitalised with eclampsia or preeclampsia, during 2014–2016. The subjects were randomly assigned to two treatment groups using blocking method based on disease (eclampsia or mild and severe preeclampsia). One group received MgSO4 (group M) and another group received phenytoin (group P) as treatment. Each group consisted of 110 and 65 women with mild and severe preeclampsia, respectively (subgroup A), and 25 women with eclampsia (subgroup B). Duration of labor, the number of cesarean sections, convulsions and Apgar scores of infants were compared between the two groups and were considered as treatment outcomes.Results: Convulsion rate was significantly lower with MgSO4 than phenytoin (P = 0.001). No seizure occurred in patients with mild preeclampsia in group P. Duration of stage one of labor (P < 0.001) and the number of cesarean sections (P = 0.040) were significantly higher in group M. However, one-minute Apgar scores for newborns were higher in women treated with MgSO4 compared to that of phenytoin (P = 0.001). Five-minute Apgar was not significantly different.Conclusion: Although MgSO4 is more effective than phenytoin for prevention of convulsion in eclampsia and severe preeclampsia, phenytoin may be considered for treatment of special conditions such as mild preeclampsia. Due to the tocolytic effects of MgSO4 on increasing the duration of labor, the increased risk of cesarean section and the potential for toxicity, physicians should critically consider the best drug according to the condition of the patient.
机译：背景：迄今为止，硫酸镁（MgSO4）是预防子痫和子痫前期癫痫发作的首选治疗方法。然而，由于它的生育溶解作用，在MgSO 4的施用中存在一些限制。这项研究的目的是比较MgSO4和另一种药物苯妥英对先兆子痫和先兆子痫患者的抗惊厥和宫缩作用。方法：这项临床试验在2014–2016年期间对住院子痫或先兆子痫的孕妇进行。使用基于疾病（子痫或轻度和重度子痫前期）的阻断方法将受试者随机分为两个治疗组。一组接受MgSO 4（M组），另一组接受苯妥英钠（P组）作为治疗。每组分别由110和65名患有先兆子痫的妇女（A组）和25名患有子痫的妇女（B组）组成。比较两组婴儿的分娩时间，剖宫产次数，惊厥次数和Apgar评分，并将其视为治疗结果。结果：MgSO4的惊厥率显着低于苯妥英钠（P = 0.001）。 P组轻度先兆子痫患者未发生癫痫发作。M组第一产程持续时间（P <0.001）和剖宫产数目（P = 0.040）明显更高。但是，新生儿的一分钟Apgar评分与苯妥英相比，用硫酸镁治疗的女性有更高的发生率（P = 0.001）。五分钟的Apgar差异无统计学意义。结论：尽管MgSO4在预防子痫和重度子痫前期惊厥方面比苯妥英更有效，但仍可考虑使用苯妥英来治疗轻度先兆子痫等特殊疾病。由于MgSO4的宫缩作用会增加分娩时间，增加剖宫产的风险和潜在的毒性，因此医师应根据患者的病情严格选择最佳药物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号