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首页> 外文期刊>Iranian Journal of Neurology >S100 B: A new concept in neurocritical care
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S100 B: A new concept in neurocritical care

机译：S100 B：神经重症监护的新概念

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After brain injuries, concentrations of some brain markers such as S100B protein in serum and cerebrospinal fluid (CSF) are correlated with the severity and outcome of brain damage. To perform an updated review of S100B roles in human neurocritical care domain, an electronic literature search was carried among articles published in English prior to March 2017. They were retrieved from PubMed, Scopus, EMBSCO, CINAHL, ISC and the Cochrane Library using keywords including “brain”, “neurobiochemical marker”, “neurocritical care”, and “S100B protein”. The integrative review included 48 studies until March 2017. S100B protein can be considered as a marker for blood brain barrier damage. The marker has an important role in the development and recovery of normal central nervous system (CNS) after injury. In addition to extra cerebral sources of S100B, the marker is principally built in the astroglial and Schwann cells. The neurobiochemical marker, S100B, has a pathognomonic role in the diagnosis of a broad spectrum of brain damage including traumatic brain injury (TBI), brain tumor, and stroke. Moreover, a potential predicting role for the neurobiochemical marker has been presumed in the efficiency of brain damage treatment and prognosis. However further animal and human studies are required before widespread routine clinical introduction of S100 protein.
机译：脑损伤后，血清和脑脊液（CSF）中某些脑标志物（例如S100B蛋白）的浓度与脑损伤的严重程度和结果相关。为了对S100B在人类神经重症监护领域的作用进行最新综述，在2017年3月之前以英文发表的文章中进行了电子文献搜索。它们使用以下关键词从PubMed，Scopus，EMBSCO，CINAHL，ISC和Cochrane图书馆中检索出来。 “大脑”，“神经生化标记”，“神经重症监护”和“ S100B蛋白”。截至2017年3月，综合评估包括48项研究。S100B蛋白可被视为血脑屏障损害的标志物。该标记在损伤后正常中枢神经系统（CNS）的发育和恢复中具有重要作用。除了S100B的额外大脑来源外，该标志物主要建立在星形胶质细胞和雪旺氏细胞中。神经生物化学标记物S100B在广泛的脑损伤（包括颅脑损伤（TBI），脑瘤和中风）的诊断中具有病理诊断作用。而且，已经推测神经生化标志物的潜在预测作用在脑损伤治疗和预后的效率中。然而，在广泛的常规临床引入S100蛋白之前，需要进一步的动物和人体研究。

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