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Prevalence of dysphagia in multiple sclerosis and its related factors: Systematic review and meta-analysis

机译:多发性硬化症吞咽困难的患病率及其相关因素:系统评价和荟萃分析

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Background: Dysphagia is the most prevalent sign of multiple sclerosis (MS) which can reduce the quality of life and augment mortality in the final stages of MS. We presented a systematic review to estimate the prevalence of dysphagia in general and separately for each evaluation method (subjective and objective), and to analyze the causes of this rampant disease. Methods: Cross-sectional and prospective cohort studies were reviewed and scientific proofs were evaluated consistent with the pre-specified levels of certainty. Results: Twenty-two articles entered the meta-analysis phase; the estimation of the general prevalence of dysphagia in MS-affected patients was 43.33% related to all the 22 studies. Moreover, the estimate of the prevalence via the subjective (16 studies) and objective (6 studies) methods were 37.21% and 58.47%, respectively. Conclusion: This study obtained the prevalence rate of dysphagia in patients affected by MS globally, yet there was infinite statistical society and limited methodological quality. Thus, more extensive studies are required for a better understanding of the global epidemiology regarding dysphagia in MS.
机译:背景:吞咽困难是多发性硬化症(MS)的最普遍征兆,在多发性硬化症的最后阶段,吞咽困难会降低生活质量并增加死亡率。我们提出了一项系统评价,以评估每种评估方法(主观和客观)的吞咽困难的总体情况,并分析这种猖ramp疾病的原因。方法:回顾性和前瞻性队列研究,并评估科学证据与预先确定的确定性水平一致。结果:22篇文章进入荟萃分析阶段;与所有22项研究相关的MS受累患者吞咽困难的普遍患病率估计为43.33%。此外,通过主观(16项研究)和客观(6项研究)方法估计的患病率分别为37.21%和58.47%。结论:本研究获得了全球MS患者吞咽困难的患病率,但统计社会无限,方法学质量有限。因此,需要更广泛的研究以更好地了解有关MS吞咽困难的全球流行病学。

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