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首页> 外文期刊>Iranian Journal of Neurology >Polymorphisms of serotonin transporter gene and psychological status in patients with multiple sclerosis
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Polymorphisms of serotonin transporter gene and psychological status in patients with multiple sclerosis

机译：多发性硬化症患者血清素转运蛋白基因多态性与心理状态

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Background: Multiple sclerosis (MS) is the most common neuroinflammatory disease in young adults. Anxiety and depression may predispose individuals to MS and flare-ups. Serotonin transmission is modified in some brain regions of patients with MS, and these changes may contribute to their psychiatric abnormalities. We studied the frequencies of common polymorphisms of the serotonin reuptake transporter (SERT) gene in patients with MS according to their psychological status. Methods: The 5-HTTLPR, rs25531, and STin2VNTR polymorphisms of the SERT gene were genotyped by polymerase chain reaction (PCR)-based methods in 100 patients with MS and 100 healthy controls. Results: There were no remarkable differences in SERT gene polymorphisms between patients with MS and healthy controls. Unlike the control group, 41% of the patients showed some degree of depression based on Beck Depression Inventory (BDI), but no association was observed between SERT gene polymorphisms after the patients were stratified by depression status. Conclusion: In addition to SERT gene polymorphisms, modulation of serotonin at the synapses may also be regulated by genetic variations in tryptophan hydroxylase type 2 and serotonin receptors. Further studies with functional brain imaging of the serotonergic system in patients with MS can provide information on the role of serotonin in this disease.
机译：背景：多发性硬化症（MS）是年轻人中最常见的神经炎性疾病。焦虑和抑郁可能会使个体容易患MS和爆发。 5-羟色胺的传递在MS患者的某些大脑区域有所改变，这些变化可能导致他们的精神异常。我们根据患者的心理状况研究了5-羟色胺再摄取转运蛋白（SERT）基因常见多态性的频率。方法：采用聚合酶链反应（PCR）方法对100例MS患者和100例健康对照者的SERT基因的5-HTTLPR，rs25531和STin2VNTR多态性进行基因分型。结果：MS患者与健康对照组的SERT基因多态性无明显差异。与对照组不同，根据贝克抑郁量表（BDI），有41％的患者表现出一定程度的抑郁，但是在根据抑郁状态对患者进行分层后，未发现SERT基因多态性之间存在关联。结论：除了SERT基因多态性，色氨酸羟化酶2型和5-羟色胺受体的遗传变异也可能调节突触时5-羟色胺的调节。 MS患者血清素能系统的功能性脑成像的进一步研究可以提供有关血清素在该疾病中的作用的信息。

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