...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>EBioMedicine >Pathogenesis of Congenital Rubella Virus Infection in Human Fetuses: Viral Infection in the Ciliary Body Could Play an Important Role in Cataractogenesis
【24h】

Pathogenesis of Congenital Rubella Virus Infection in Human Fetuses: Viral Infection in the Ciliary Body Could Play an Important Role in Cataractogenesis

机译：人类胎儿先天性风疹病毒感染的发病机制：睫状体中的病毒感染可能在白内障发生中起重要作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Development of congenital rubella syndrome associated with rubella virus infection during pregnancy is clinically important, but the pathogenicity of the virus remains unclear. Methods: Pathological examination was conducted on 3 aborted fetuses with congenital rubella infection. Findings: At autopsy, all 3 aborted fetuses showed congenital cataract confirmed by gross observation. Rubella virus infection occurred via systemic organs including circulating hematopoietic stem cells confirmed by immunohistochemical and molecular investigations, and major histopathogical changes were found in the liver. It is noteworthy that the virus infected the ciliary body of the eye, suggesting a possible cause of cataracts. Interpretation: Our study based on the pathological examination demonstrated that the rubella virus infection occurred via systemic organs of human fetuses. This fact was confirmed by immunohistochemistry and direct detection of viral RNA in multiple organs. To the best of our knowledge, this study is the first report demonstrating that the rubella virus infection occurred via systemic organs of the human body. Importantly, virus infection of the ciliary body could play an important role in cataractogenesis.
机译：背景：与怀孕期间风疹病毒感染相关的先天性风疹综合征的发展在临床上很重要，但该病毒的致病性仍不清楚。方法：对3例先天性风疹感染的流产胎儿进行了病理检查。结果：尸检时，所有3名流产的胎儿均表现为先天性白内障，经肉眼观察证实。风疹病毒感染是通过全身器官发生的，包括免疫组织化学和分子研究证实的循环造血干细胞，并且在肝脏中发现了主要的组织病理学变化。值得注意的是，该病毒感染了眼睫状体，提示可能是白内障的原因。解释：我们基于病理检查的研究表明风疹病毒感染是通过人类胎儿的全身器官发生的。免疫组织化学和在多个器官中直接检测病毒RNA证实了这一事实。据我们所知，这项研究是第一份证明风疹病毒感染是通过人体系统器官发生的报告。重要的是，睫状体的病毒感染可能在白内障发生中起重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号