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首页> 外文期刊>Iranian Journal of Reproductive Medicine >THE EFFECTS OF DIFFERENT LUTEAL SUPPORT HORMONES ON ENDOMETRIAL ALKALINE PHOSPHATASE ACTIVITY AND ENDOMETRIAL THICKNESS IN SUPEROVULATED MICE
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THE EFFECTS OF DIFFERENT LUTEAL SUPPORT HORMONES ON ENDOMETRIAL ALKALINE PHOSPHATASE ACTIVITY AND ENDOMETRIAL THICKNESS IN SUPEROVULATED MICE

机译：不同促黄体激素对超血管形成小鼠子宫内膜碱性磷酸酶活性和子宫内膜厚度的影响

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Background: There are some controversial data on application of progesterone and progesterone plus estrogen at luteal phase. Objective: To investigate the effects of different luteal support hormones on the Alkaline Phosphates (ALP) activity in the endometrial epithelium and endometrial thickness during superovulation process for obtaining the optimized endometrial receptivity in animal model.Materials and Methods: Pseudopregnant female Balb/c mice were induced for pseudopregnany through superovulation then the mice were divided into two groups. Experimental group included five groups: the pseudopregnant mice were given four consecutive, daily injections of progesterone (P group), estrogen (E group), estrogen + progesterone (E+P group), antiprogesterone + estrogen (RU 486 + E), and sham group. In the control group, pseudopregnancy was induced in the natural cycle. The uterus was collected after day 4.5 of pseudopregnancy. The samples were prepared for the morphological and morphometrical evaluation of the endometrial ALP activity and endometrial thickness.Results: ALP activity was observed in all groups except P group. ALP activity of P + E group was similar to E and RU 486 + E groups. Sham group showed high ALP activity compared to the P group. The endometrial thickness was low in the P group and high in the sham group in comparison with other groups.Conclusion: In conclusion, super ovulation decreased the ALP activity. Estrogen along with progesterone at the luteal phase increased the enzyme activity and the endometrial thickness, compared with the progesterone administration, and thus, progesterone plus estrogen could improve embryo receptivity.
机译：背景：关于黄体期孕酮和孕酮加雌激素的应用存在争议。目的：研究不同黄体支持激素对超排卵过程中子宫内膜上皮碱性磷酸酶（ALP）活性和子宫内膜厚度的影响，以优化动物模型的子宫内膜容受性。方法与方法：假孕雌性Balb / c小鼠通过超排卵诱导假孕，然后将小鼠分为两组。实验组包括五组：对假孕小鼠连续四次每天注射黄体酮（P组），雌激素（E组），雌激素+黄体酮（E + P组），抗孕酮+雌激素（RU 486 + E）和假组。对照组在自然周期中诱发假性妊娠。假怀孕第4.5天后收集子宫。制备样品用于子宫内膜ALP活性和子宫内膜厚度的形态学和形态计量学评价。结果：除P组外，所有组均观察到ALP活性。 P + E组的ALP活性类似于E和RU 486 + E组。与P组相比，Sham组显示出较高的ALP活性。与其他组相比，P组子宫内膜厚度低，假手术组子宫内膜厚度高。结论：总的来说，超排卵降低了ALP活性。与黄体酮给药相比，黄体期的雌激素和黄体酮增加了酶的活性和子宫内膜厚度，因此黄体酮加雌激素可以提高胚胎的接受能力。

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