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首页> 外文期刊>Iranian red crescent medical journal >Haplotype Analysis of Hemochromatosis Gene Polymorphisms in Chronic Hepatitis C Virus Infection: A Case Control Study
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Haplotype Analysis of Hemochromatosis Gene Polymorphisms in Chronic Hepatitis C Virus Infection: A Case Control Study

机译：慢性丙型肝炎病毒感染中血色素沉着病基因多态性的单倍型分析：病例对照研究

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Chronic hepatitis C virus (HCV) infection is frequently associated with elevated serum iron markers. Polymorphisms in the hemochromatosis (HFE) genes are responsible for iron accumulation in most cases of hemochromatosis, and may play a role in HCV infection. Objectives: We aimed to assess the prevalence of HFE gene polymorphisms in a group of Iranian HCV-infected patients, and to explore the association of these polymorphisms with HCV infection. Patients and Methods: HFE gene polymorphisms were examined in a total of 69 HCV patients and 69 healthy controls using polymerase chain reaction and restriction fragment length polymorphism techniques. Haplotype and diplotype analyses were performed using PHASE software. Results: In a recessive analysis model of the His63Asp (H63D) locus (HH vs. HD + DD), the HH genotype was more common in patients compared to controls (adjusted P = 0.012; OR = 6.42 [95% CI: 1.51 - 27.33]). Also, in a recessive analysis model of the Cys282Tyr (C282Y) locus (CC vs. CY + YY), the CC genotype was more frequent in patients compared to controls (adjusted P = 0.03; OR = 5.06 [95% CI: 1.13 - 22.06]). In addition, there was a significant association between the HC haplotype and the HCDC diplotype and HCV infection. Conclusions: Polymorphism in the hemochromatosis gene may confer some degree of risk for HCV infection, and individuals carrying the H and C alleles may be susceptible to this disease; however, a larger sample of HCV patients and healthy individuals may be necessary to further illustrate the role of these polymorphisms in HCV.
机译：慢性丙型肝炎病毒（HCV）感染通常与血清铁标志物升高有关。在大多数血色素沉着病病例中，血色素沉着病（HFE）基因的多态性可导致铁积累，并可能在HCV感染中起作用。目的：我们旨在评估一组伊朗HCV感染患者中HFE基因多态性的患病率，并探讨这些多态性与HCV感染的关系。患者和方法：使用聚合酶链反应和限制性片段长度多态性技术，对总共69名HCV患者和69名健康对照者的HFE基因多态性进行了检查。使用PHASE软件进行单倍型和双倍型分析。结果：在His63Asp（H63D）基因座的隐性分析模型（HH vs. HD + DD）中，与对照组相比，HH基因型在患者中更为常见（校正后P = 0.012; OR = 6.42 [95％CI：1.51- 27.33]）。此外，在Cys282Tyr（C282Y）基因座的隐性分析模型（CC与CY + YY）中，与对照组相比，患者的CC基因型更为常见（校正后P = 0.03; OR = 5.06 [95％CI：1.13- 22.06]）。此外，HC单倍型与HCDC双倍型和HCV感染之间存在显着关联。结论：血色素沉着病基因的多态性可能会在某种程度上赋予HCV感染风险，携带H和C等位基因的个体可能易患此病。但是，可能需要更多的HCV患者和健康个体样本以进一步说明这些多态性在HCV中的作用。

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