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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Genotoxic damage in cultured human peripheral blood lymphocytes of oral contraceptive users
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Genotoxic damage in cultured human peripheral blood lymphocytes of oral contraceptive users

机译：口服避孕药使用者培养的人外周血淋巴细胞的遗传毒性损害

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摘要

Synthetic progestins and estrogens have been reported to be toxic in various experimental models. Their prolonged use has been reported to induce cancer in humans. In the present study the effects of oral contraceptives were studied among users using chromosomal aberrations, sister chromatid exchanges and DNA damage as a parameter, in cultured human peripheral blood lymphocytes. The study was performed on 25 women (users) and 25 age match controls. No significant difference was observed in chromosomal aberrations and DNA damage. A significant increase was observed in sister chromatid exchanges (SCEs) Cell among users. The results obtained and the risk of oral contraceptives (OCs) genotoxicity have been discussed.
机译：据报道，合成的孕激素和雌激素在各种实验模型中均具有毒性。据报道，长时间使用它们会诱发人类癌症。在本研究中，使用培养的人外周血淋巴细胞中的染色体畸变，姐妹染色单体交换和DNA损伤为参数，研究了口服避孕药的效果。该研究针对25位女性（使用者）和25位年龄匹配的对照组进行。在染色体畸变和DNA损伤方面未观察到显着差异。使用者之间的姐妹染色单体交换（SCE）细胞显着增加。讨论了获得的结果以及口服避孕药（OCs）遗传毒性的风险。

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