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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Impact of cell death pathway genes Fas 21377AA and FasL 2844CC polymorphisms on the risk of developing non-small cell lung cancer
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Impact of cell death pathway genes Fas 21377AA and FasL 2844CC polymorphisms on the risk of developing non-small cell lung cancer

机译：细胞死亡途径基因Fas 21377AA和FasL 2844CC多态性对发展非小细胞肺癌风险的影响

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Background The signalling pathway Fas and FasL system plays a fundamental role in the regulation of apoptotic cell death and any disturbance of this pathway has been shown to promote immune escape and tumorigenesis. Many types of cancers show reduced expression of FAS and elevated FasL expression. The Fas21377G/A, and FasL2844T/C polymorphisms might be associated with increased risk of lung cancer. Objective The interplay between genetic polymorphisms could participate in cancer development. This study aimed to examine the contribution of Fas21377AA and FasL2844CC genotypes to risk of developing lung cancer. Subjects and methods A case-control study was conducted on 20 non small cell lung cancer (NSCLC) cases and 40 controls. Genotyping of Fas 21377AA and FasL 2844CC Single nucleotide polymorphisms (SNPs) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) were done to all subjects. Results The distribution of Fas and FasL genotypes showed a higher frequency of Fas AA genotype among patients compared to controls with an increased risk of lung cancer (OR 5.28; CI:1.35–20.65, P value .01). No statistically significant difference was found between patients and controls groups in respect to FasL genotypes. Gene to gene interaction between Fas and FasL genotypes showed significant differences between the patients and controls groups. As regards the combination between FasL TT+CT & Fas AA, FasL CC & Fas GG+GA and FasL CC & Fas AA genotypes where patients carrying FasL CC or Fas AA genotypes have increased risk to develop lung cancer, (OR 10.28, 95% CI; 1.68–62.74, P value .01), (OR 72, 95% CI; 5.55–132.99, P value .001) and (OR 9, 95% CI; 1.5–53.86, P value .01) respectively. The FasL-CC genotype showed 2.25 folds increased risk to develop lung cancer in non-smoker patients, P?=?.008. No correlation was found between the pathological types, the stage of lung cancer and the Fas and FasL genotypes. Conclusion The interaction of the cell death pathway genes Fas and FasL polymorphisms could be associated with the risk of lung cancer, in the same respect Fas AA genotype could also potentiate this risk.
机译：背景信号转导途径Fas和FasL系统在凋亡细胞死亡的调节中起着基本作用，并且对该途径的任何干扰均已显示出可促进免疫逃逸和肿瘤发生。许多类型的癌症显示出FAS表达降低和FasL表达升高。 Fas21377G / A和FasL2844T / C多态性可能与肺癌风险增加有关。目的基因多态性之间的相互作用可能参与癌症的发展。这项研究旨在检查Fas21377AA和FasL2844CC基因型对肺癌发生风险的贡献。对象和方法对20例非小细胞肺癌（NSCLC）病例和40例对照进行了病例对照研究。 Fas 21377AA和FasL 2844CC的基因分型通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）进行的所有受试者。结果Fas和FasL基因型的分布显示，与患肺癌风险增加的对照组相比，患者中Fas AA基因型的频率更高（OR 5.28; CI：1.35–20.65，P值.01）。 FasL基因型在患者和对照组之间没有发现统计学上的显着差异。 Fas和FasL基因型之间的基因对基因相互作用显示，患者和对照组之间存在显着差异。对于FasL TT + CT和Fas AA，FasL CC和Fas GG + GA和FasL CC和Fas AA基因型之间的组合，携带FasL CC或Fas AA基因型的患者罹患肺癌的风险增加，（OR 10.28，95％ CI; 1.68-62.74，P值.01），（OR 72，95％CI; 5.55-132.99，P值.001）和（OR 9，95％CI; 1.5-53.86，P值0.01）。 FasL-CC基因型显示出非吸烟者患肺癌的风险增加了2.25倍，P == 0.008。在病理类型，肺癌分期以及Fas和FasL基因型之间未发现相关性。结论细胞死亡通路基因Fas和FasL多态性的相互作用可能与肺癌的风险有关，在同一方面，Fas AA基因型也可以增强肺癌的风险。

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