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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Association of interleukin-6 and its -174G/C promoter polymorphism with clinical and laboratory characteristics of non hepatitis C virus rheumatoid arthritis patients
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Association of interleukin-6 and its -174G/C promoter polymorphism with clinical and laboratory characteristics of non hepatitis C virus rheumatoid arthritis patients

机译：白细胞介素6及其-174G / C启动子多态性与非丙型肝炎病毒类风湿关节炎患者临床和实验室特征的关系

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Background Interleukin-6 is a cytokine protein, which causes inflammation, maintains immune homeostasis and shows a role in rheumatoid arthritis pathogenesis. IL-6-174G/C promoter polymorphism may have a role in susceptibility to RA. Aim of the work To evaluate the clinical significance of serum levels of IL-6 and its -174G/C promoter polymorphism in RA patients in comparison with the controls. Patients and methods This study enrolled 25 non hepatitis C virus RA patients versus 25 age and gender matched controls. Demographic, clinical and laboratory data were prospectively evaluated. Serum IL-6 level and promoter (-174G/C) genotype were determined. Results Serum IL-6 levels was significantly higher in RA patients compared to control subjects ( p?= ?.001), especially those with CC promoter polymorphism. There was a significant correlation between IL and 6 level and duration of morning stiffness, disease activity, hemoglobin concentration and ESR level. 15/25 patients had (-174G/G) gene promoter polymorphism, 8/25 were GC and 2/25 were CC. All controls were GG. There was significant association between gene polymorphism and age at disease onset ( p?= ?.0172), which was older in those with GG genotype (38.5?±?10.25?years) than those with CC (33.5?±?0.71?years) and younger in GC genotypes (27.9?±?7.9?years). None of the other clinical, laboratory or radiological parameters would predict the IL-6 promoter polymorphism. Conclusion Serum IL-6 levels and -174G/C promoter polymorphism were higher in RA patients than in healthy controls. The positive correlation of IL-6 level with the DAS28 and duration of morning stiffness may confirm its’ increased involvement in the pathogenesis of RA and may point to the need for considering of anti-IL-6 agents in their management plan. The negative correlation of IL-6 level with the hemoglobin level may confirm IL-6 play a significant role in anemia of RA.
机译：背景白介素-6是一种细胞因子蛋白，可引起炎症，维持免疫稳态并在类风湿性关节炎的发病机理中发挥作用。 IL-6-174G / C启动子多态性可能对RA敏感。工作目的与对照组比较，评估RA患者血清IL-6水平及其-174G / C启动子多态性的临床意义。患者和方法本研究招募了25名非丙型肝炎病毒性RA患者与25名年龄和性别相匹配的对照组。人口，临床和实验室数据进行了前瞻性评估。测定血清IL-6水平和启动子（-174G / C）基因型。结果与对照组相比，RA患者的血清IL-6水平显着更高（p = 0.001），尤其是那些具有CC启动子多态性的患者。 IL和6水平与晨僵持续时间，疾病活动性，血红蛋白浓度和ESR水平之间存在显着相关性。 15/25例患者具有（-174G / G）基因启动子多态性，GC占8/25，CC占2/25。所有对照均为GG。基因多态性与疾病发作年龄之间存在显着相关性（p？= ?. 0172），与GG基因型（38.5？±10.25？年）相比，GG基因型年龄更大（33.5？±？10.25？年）。 ）和更年轻的GC基因型（27.9？±？7.9？岁）。其他临床，实验室或放射学参数均无法预测IL-6启动子多态性。结论RA患者的血清IL-6水平和-174G / C启动子多态性高于健康对照组。 IL-6水平与DAS28和早晨僵直的持续时间呈正相关，这可能证实它与RA的发病机制有关，并且可能表明在其治疗计划中需要考虑使用抗IL-6药物。 IL-6水平与血红蛋白水平呈负相关可能证实IL-6在RA贫血中起重要作用。

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