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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >The population structure of Ukraine in relation to the phenylthiocarbamide sensitivity
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The population structure of Ukraine in relation to the phenylthiocarbamide sensitivity

机译：乌克兰的人口结构与苯硫脲敏感性

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Background The taste sensitivity to phenylthiocarbamide (PTC) is one of the classical genetic markers in human studies. PTC is of great interest from the medical point of view since a number of associations of the taster status with human diseases have been found. The aim of our study was to evaluate the population structure of Ukraine in relation to PTC sensitivity. Methods The study involved 533 people (78 males and 455 females) aged from 16 to 25years. The PTC solution in the concentration of 0.13% was prepared according to the method of Harris and Kalmus. The participants of the study analyzed the taste of the filter paper impregnated with PTC. If the trial subjects tasted PTC as “bitter”, “very bitter”, “bitterish”, the phenotype was defined as a taster. If the trial subject did not taste PTC (“no taste”, “taste of paper”), he/she was referred to a non-taster. Results The structure of the sample of the Ukrainian population studied in relation to the phenotypic and genotypic frequency associated with the phenylthiocarbamide sensitivity has been studied. It has been shown that in the population there are 22% of those who do not feel the taste of phenylthiocarbamide. Among males there are a few more non-tasters than among females, however, the differences are not significant. The frequency of the dominant and recessive allele of the phenylthiocarbamide sensitivity gene in the sample calculated on the basis of the Hardy–Weinberg equation is generally p T =0.55 and q t =0.45, respectively. Conclusions Frequencies of alleles T and t obtained in the male and female population under research are very close to the frequencies of the same alleles in some populations of India. Data of this study supplement the currently available information in relation to the genetic structure of modern Ukrainian cities.
机译：背景技术对苯硫脲（PTC）的味觉敏感性是人类研究中的经典遗传标记之一。从医学的角度来看，PTC引起了极大的兴趣，因为已经发现了许多品尝者地位与人类疾病的关联。我们研究的目的是评估与PTC敏感性相关的乌克兰人口结构。方法这项研究涉及533位年龄在16至25岁之间的人（男78位，女455位）。根据Harris和Kalmus的方法制备浓度为0.13％的PTC溶液。研究的参与者分析了浸有PTC的滤纸的味道。如果试验对象将PTC视为“苦”，“非常苦”，“苦”，则将表型定义为品尝者。如果试验对象没有品尝PTC（“没有味道”，“纸上的味道”），则将他/她称为非品尝者。结果研究了与苯硫脲敏感性相关的表型和基因型频率相关的乌克兰人口样本结构。研究表明，在人口中有22％的人不感觉到苯硫脲的味道。在男性中，非品尝者比女性中少一些，但是差异并不显着。根据Hardy-Weinberg方程计算得出的样品中苯硫脲酰胺敏感性基因的优势和隐性等位基因频率通常分别为p T = 0.55和q t = 0.45。结论在所研究的男性和女性人群中获得的等位基因T和t的频率非常接近印度某些人群中相同等位基因的频率。这项研究的数据补充了有关现代乌克兰城市遗传结构的当前可用信息。

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