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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Role of MTHFR A1298C gene polymorphism in the etiology of prostate cancer: A systematic review and updated meta-analysis
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Role of MTHFR A1298C gene polymorphism in the etiology of prostate cancer: A systematic review and updated meta-analysis

机译： MTHFR A1298C基因多态性在前列腺癌病因学中的作用：系统评价和最新荟萃分析

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Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate/homocysteine pathway and is essential for synthesis, repair and methylation of DNA. Various studies have performed to evaluate the role of MTHFR A1298C gene polymorphism to the risk of prostate cancer and the results were inconclusive and inconsistent. A meta-analysis of published case-control studies, up to December 2014, was performed to investigate the association between MTHFR A1298C gene polymorphism and the susceptibility of prostate cancer. PubMed, Science direct, Springer link and Google scholar databases were searched for case-control studies and crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of association. The analyses were conducted with Open Meta-Analyst and MIX softwares. Total thirteen case-control studies with 4673 prostate cancer patients and 6982 controls were included in this meta-analysis. No associations were observed between MTHFR A1298C gene polymorphism and prostate cancer in any genetic model (allele contrast (C vs. A): OR = 1.01; 95% CI: 0.91–1.13; p = 0.73; dominant model (CC + AC vs. AA): OR = 0.98, 95% CI = 0.91–1.06, p = 0.73; homozygote model (CC vs. AA): OR = 0.96, 95% CI = 0.83–1.10, p = 0.55; co-dominant model (AC vs. AA): OR = 0.98, 95% CI = 0.91–1.07, p = 0.76; and recessive model (CC vs. AC + AA): OR = 0.96, 95% CI = 0.84–1.10, p = 0.61). Moreover, when the data were stratified on the basis of ethnicity no significant associations were observed. The results of the present meta-analysis suggest that the MTHFR A1298C gene polymorphism has no effect on the etiology of prostate cancer.
机译：亚甲基四氢叶酸还原酶（MTHFR）是叶酸/高半胱氨酸途径的重要酶，对于DNA的合成，修复和甲基化必不可少。进行了各种研究以评估MTHFR A1298C基因多态性对前列腺癌风险的作用，结果尚无定论且不一致。对截至2014年12月的已发表病例对照研究进行荟萃分析，以研究MTHFR A1298C基因多态性与前列腺癌易感性之间的关系。搜索PubMed，Science direct，Springer链接和Google Scholar数据库以进行病例对照研究，并计算具有95％置信区间（CI）的原始比值比（OR）以估计关联强度。使用Open Meta-Analyst和MIX软件进行分析。这项荟萃分析共包括13例病例对照研究，涉及4673例前列腺癌患者和6982例对照。在任何遗传模型中，均未观察到MTHFR A1298C基因多态性与前列腺癌之间的关联（等位基因对比（C vs. A）：OR = 1.01; 95％CI：0.91-1.13; p = 0.73;优势模型（CC + AC vs. A）。 AA）：OR = 0.98，95％CI = 0.91–1.06，p = 0.73;纯合子模型（CC与AA）：OR = 0.96，95％CI = 0.83-1.10，p = 0.55;共显性模型（AC相对于AA）：OR = 0.98，95％CI = 0.91–1.07，p = 0.76;以及隐性模型（CC与AC + AA）：OR = 0.96，95％CI = 0.84–1.10，p = 0.61）。此外，当根据种族对数据进行分层时，没有发现显着的关联。本荟萃分析的结果表明，MTHFR A1298C基因多态性对前列腺癌的病因没有影响。

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