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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Exploring the link between VDR rs2228570 and uterine leiomyoma in Iranian women
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Exploring the link between VDR rs2228570 and uterine leiomyoma in Iranian women

机译：探索VDR rs2228570与伊朗女性子宫平滑肌瘤之间的联系

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Evidences are growing toward an inhibitory role of vitamin D3 in uterine leiomyoma pathogenesis. Uterine leiomyoma commonly affects women of reproductive age and is referred to as one of the most common indications for hysterectomy, worldwide. The effects of vitamin D are mediated through the vitamin D receptor. A single nucleotide polymorphism of the VDR gene results in longer protein with decreased activity. The present study has focused on the distribution of FokI polymorphism in Iranian patients with uterine leiomyoma. Using the PCR-RFLP method 45 cases and 53 controls were assessed. The results demonstrated a correlation between VDR TT genotype and uterine leiomyoma by Odds Ratio of 1.886 (CI, .767–4.640). The examination of heterozygous CT genotype also showed the same result by Odds Ratio of 1.875 (CI, .629–5.590). This study lends support for an increased risk of uterine leiomyoma associated with the VDR rs2228570 polymorphism. To the best of our knowledge this is the first report regarding VDR FokI polymorphism in leiomyoma patients.
机译：越来越多的证据表明维生素D3在子宫肌瘤的发病机理中具有抑制作用。子宫平滑肌瘤通常会影响育龄妇女，在世界范围内被称为子宫切除术的最常见适应症之一。维生素D的作用是通过维生素D受体介导的。 VDR基因的单核苷酸多态性导致蛋白质更长，活性降低。本研究集中在伊朗子宫平滑肌瘤患者中FokI多态性的分布。使用PCR-RFLP方法评估了45例病例和53个对照。结果表明，VDR TT基因型与子宫平滑肌瘤之间的相关性为1.886（CI，.767–4.640）。杂合CT基因型检查也显示出相同的结果，赔率比为1.875（CI，.629-5.590）。这项研究为与VDR rs2228570多态性相关的子宫平滑肌瘤风险增加提供了支持。据我们所知，这是关于平滑肌瘤患者VDR FokI多态性的首次报道。

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