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首页> 外文期刊>Iranian Journal of Reproductive Medicine >MORPHOLOGICAL AND MORPHOMETRICAL CHANGES OF ENDOMETRIM AFTER APPLICATION OF ESTROGEN AND PROGESTERONE DURING LUTEAL PHASE IN THE SUPEROVULATED MICE
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MORPHOLOGICAL AND MORPHOMETRICAL CHANGES OF ENDOMETRIM AFTER APPLICATION OF ESTROGEN AND PROGESTERONE DURING LUTEAL PHASE IN THE SUPEROVULATED MICE

机译：超排卵小鼠黄体期黄体酮注入后子宫内膜的形态和形态变化。

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Background: The application of luteal phase supplementation hormones to increase the implantation rate is on debate among researchers.Objective: In this study, the morphological and morphometrical assessment of superovulated mice endometrium were investigated at window implantation period superovulated mice.Materials and Methods: Female mice were superovualated then were mated with vasectomized mice; the mice were divided in experimental and control groups. Experimental group included five groups which in them pseudopregnant mice were given a four consecutive daily injection of 1-progesterone (P), 2-estrogen (E), 3- estrogen + progesterone, 4-antiprogesterone+estrogen and 5-sham group. The uterine of all groups were collected after 4.5 day of pseudopregnancy and were prepared for histological and morphometrical studies.Results: Morphological studies of endometrial tissue showed that the luminal epithelium in group P appeared cuboidal shape. Endometrial folding was very high in group E+P. The luminal epithelium in groups E, E+P and RU 486 + E were seen in different morphology in comparison to control group. Morphometrical evaluation also showed height of luminal epithelium in group E (32.7?±0.67) and E+P (33.6?±1.3) were higher than those were seen in control (22.5?±1.5) and group P (15.3?±1.2). Conclusion: Progesterone caused the lowest endometrial development compare to other groups. It is concluded that the adding of E to P may improve endometrial condition to implant at luteal phase.
机译：背景：黄体期补充激素在提高植入率方面的研究一直在争论中。目的：在这项研究中，研究了超排卵小鼠在子宫着床期子宫内膜的形态学和形态计量学评价。材料与方法：雌性小鼠超排卵，然后与输精管切除的小鼠交配;将小鼠分为实验组和对照组。实验组包括五组，其中给假孕小鼠连续四天每天注射1-孕酮（P），2-雌激素（E），3-雌激素+孕酮，4-抗孕酮+雌激素和5-sham组。假孕4.5天后收集各组子宫，进行组织学和形态计量学研究。结果：子宫内膜组织的形态学检查显示，P组腔上皮呈长方体状。 E + P组子宫内膜折叠非常高。与对照组相比，E，E + P和RU 486 + E组的腔上皮形态不同。形态计量学评估还显示，E组（32.7±0.67）和E + P（33.6±±1.3）的腔上皮高度均高于对照组（22.5±±1.5）和P组（15.3±±1.2）。 。结论：与其他组相比，孕酮引起的子宫内膜发育最低。结论：在P中添加E可以改善黄体期植入的子宫内膜状况。

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