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首页> 外文期刊>Iranian Journal of Reproductive Medicine >VITAMINS C, E AND LIPID PEROXIDATION LEVELS IN SPERM AND SEMINAL PLASMA OF ASTHENOTERATOZOOSPERMIC AND NORMOZOOSPERMIC MEN
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VITAMINS C, E AND LIPID PEROXIDATION LEVELS IN SPERM AND SEMINAL PLASMA OF ASTHENOTERATOZOOSPERMIC AND NORMOZOOSPERMIC MEN

机译：男性，精子和精子的精子和半血浆中维生素C，E和脂质过氧化水平

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Background: It has been shown that reactive oxygen species (ROS) can lead to deleterious effects on a range of sperm parameters. Vitamins E and C are capable of reducing ROS levels and lipid peroxidation.Objective: The aim of study was to determine the level of lipid peroxidation as indicated by Malondialdehyde (MDA) and vitamins E and C in sperm and seminal plasma of asthenoteratozoospermic and normozoospermic men and their relationships with semen parameters.Materials and Methods: Forty men with normozoospermic and 60 infertile men with asthenoteratozoospermic semen profiles were randomly selected. Semen analysis was done according to the WHO standard. Sex hormonal profiles were measured by ELISA methods. The level of vitamins (C and E) and MDA were measured by HPLC and tiobarbiotic acid, respectively.Results: MDA concentration in the spermatozoa (0.1?±0.06 nmol/ml) and seminal plasma (1.9?±0.35 nmol/ml) of asthenoteratozoospermic were significantly higher than in normozoospermic males (p0.001).The level of vitamins E and C in seminal plasma of normozoospermic were significantly higher than in asthenoteratozoospermic males (p0.01). However, the amount of vitamin C in the spermatozoa of normozoospermic was significantly less than in asthenoteratozoospermic males (p0.01). Sensitivity, specificity, positive and negative prognostic value of MDA of seminal plasma and spermatozoa were more than vitamins C and E. The level of vitamin C of spermatozoa had more diagnostic value when compare to vitamins C and E in seminal plasma. Conclusion: The level of MDA in seminal plasma and spermatozoa and vitamin C in spermatozoa may be a diagnostic tool for etiology of infertility in the asthenoteratozoospermic patients.
机译：背景：研究表明，活性氧（ROS）可能对一系列精子参数产生有害影响。维生素E和C能够降低ROS水平和脂质过氧化作用。目的：研究旨在确定丙二醛（MDA）和维生素E和C在无精症和精子代精子症男性精子和精浆中所表现出的脂质过氧化水平。材料与方法：方法：随机选择40例正常精子症男性和60例非精囊性精子男性。精液分析是根据WHO标准进行的。通过ELISA方法测量性激素概况。结果：精子中精子的MDA浓度为0.1？±0.06 nmol / ml，精浆中的MDA浓度为1.9？±0.35 nmol / ml。正常精子的精子血浆明显高于正常精子的男性（p <0.001）。精子精浆中维生素E和C的水平明显高于正常精子的男性（p <0.01）。但是，正常精子精子中维生素C的含量显着低于无精子症的男性（p <0.01）。精浆和精子MDA的敏感性，特异性，阳性和阴性预后值均高于维生素C和E。精浆中维生素C的水平高于精浆中的维生素C和E。结论：精浆和精子中的MDA含量以及精子中的维生素C可能是诊断动脉粥样硬化性不育症的不孕原因的诊断工具。

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