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首页> 外文期刊>Iranian Journal of Reproductive Medicine >CORRELATION OF SPERM MORPHOLOGY AND OXIDATIVE STRESS IN INFERTILE MEN
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CORRELATION OF SPERM MORPHOLOGY AND OXIDATIVE STRESS IN INFERTILE MEN

机译：异型男人精子形态与氧化应激的相关性

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Background: Excess reactive oxygen species (ROS) in the semen is believed to affect fertility in men. Morphologically abnormal sperms and their relation to seminal oxidative stress in infertile and subfertile men are not clear. Objective: To correlate various sperm morphological defects with seminal oxidative stress in infertile and subfertile men. Materials and Methods: The study included 25 primary, 21 secondary infertile men of idiopathic infertility and 15 fertile controls. Standard semen analysis was performed according to WHO (1999) guidelines. Sperm inter-morphological defects were evaluated in 100 sperms per sample by Giemsa staining. ROS in spermatozoa was measured by the chemiluminescence assay. Results: Significant difference in percent sperm amorphous head was found between secondary infertile group and control men. The study showed a significantly higher percent spermatozoa with residual cytoplasm between primary [11.61 (6.6, 3.9)], secondary [7.49 (0.8, 13)] and fertile controls [2.44 (0.8, 3.7)] similar to sperm count, percent sperm progressive motility, and ROS levels. A non significant but strong positive correlation (r=0.3479, p=0.0884) between percent cytoplasmic retained spermatozoa and ROS levels was observed in the primary infertile group. However, no correlation between other sperm morphological defects and oxidative stress was observed. Conclusion: Sperm morphology was not found to be associated with oxidative stress in the present study. However, retained cytoplasmic residues in the sperm may be an important source of ROS in both primary and secondary infertile men. These immature spermatozoa are believed to be associated with impaired fertility.
机译：背景：精液中过量的活性氧（ROS）被认为会影响男性的生育能力。不育和亚不育男性的形态学异常精子及其与精子氧化应激的关系尚不清楚。目的：将不育和亚不育男性的各种精子形态缺陷与精子氧化应激相关联。材料和方法：该研究包括25名原发性不育的原发性不育男性，21名继发性不育男性和15名可育对照。根据WHO（1999）指南进行标准精液分析。通过吉姆萨染色评估每个样品100个精子中的精子形态学缺陷。通过化学发光测定法测量精子中的ROS。结果：继发性不育组与对照组男性之间的精子无定形头百分比差异显着。研究显示，精子百分比显着更高，剩余细胞质介于原发[11.61（6.6，3.9）]，继发[7.49（0.8，13）]和可育对照[2.44（0.8，3.7）]之间，与精子数量相似，精子进展百分比活力和ROS水平。在原发性不育组中观察到细胞质保留精子百分率与ROS水平之间无显着但强正相关（r = 0.3479，p = 0.0884）。但是，没有观察到其他精子形态缺陷与氧化应激之间的相关性。结论：本研究中未发现精子形态与氧化应激有关。然而，在原发性和继发性不育男性中，精子中残留的细胞质残留可能是ROS的重要来源。这些未成熟的精子被认为与生育能力受损有关。

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