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首页> 外文期刊>Iranian Journal of Reproductive Medicine >EFFECT OF WITHANIA SOMNIFERA ON LEVELS OF SEX HORMONES IN THE DIABETIC MALE RATS
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EFFECT OF WITHANIA SOMNIFERA ON LEVELS OF SEX HORMONES IN THE DIABETIC MALE RATS

机译：茄子枯萎病对糖尿病大鼠性激素水平的影响

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Background: There are evidences regarding the prevalence of dysfunction in sexual function and behavior in diabetic people. Experimental studies revealed a positive effect of withania somnifera on sexual function and behaviors.Objective: In this research, the effect of withania somnifera on sexual function in diabetic male Wistar rats was assessed by measuring the serum levels of testosterone, progesterone, estrogen, FSH and LH.Materials and Methods: Experimental diabetes mellitus type I was induced by intraperitoneal injection of a single dose (60 mg/kg) of streptozotocin (STZ) in Wistar male rats. Oral withania somnifera root was given in pelleted food at ratio of 6.25% for 4 weeks. The levels of gonadadotropic hormones (LH, FSH), progesterone, estrogen and testosterone in animalsa€? serum were determined after 4 weeks in all groups. Results: Withania somnifera root was effective in lowering FSH serum level in somnifera-treated animals compared to controls (p0.05) in both diabetic and non-diabetic groups, whereas progesterone (p0.05), testosterone (p0.05) and LH levels (p0.001) were significantly higher in non-diabetic treated animals. Oral somnifera root was also able to reverse the reductive effect of diabetes on the progesterone. The estrogen level did not show any significant difference in any of the groups.Conclusion: It is suggested that withania somnifera may have a regulatory effect on diabetes-induced change of the levels of gonadal-hormones, especially progesterone, in male rats. Nevertheless, somnifera is apparently only able to diminish FSH serum level in intact animals.  
机译：背景：有证据表明，糖尿病患者性功能和行为障碍的患病率很高。实验研究表明，withania somnifera对性功能和行为具有积极作用。目的：通过测量血清睾丸激素，孕激素，雌激素，FSH和材料与方法：实验性I型糖尿病是通过腹腔注射Wistar雄性大鼠单剂量（60 mg / kg）链脲佐菌素（STZ）诱发的。在颗粒食品中以6.25％的比例口服茄子根，连用4周。动物体内的促性腺激素（LH，FSH），孕酮，雌激素和睾丸激素的水平所有组在4周后测定血清。结果：在糖尿病组和非糖尿病组中，Withania somnifera根均能有效地降低与对照组（p <0.05）相比，用smnifera治疗的动物的FSH血清水平，而孕酮（p <0.05），睾丸激素（p <0.05）和LH在非糖尿病治疗的动物中，血脂水平（p <0.001）显着更高。口服睡草根还能够逆转糖尿病对孕酮的还原作用。结论：茄子碱对糖尿病引起的雄性大鼠性腺激素尤其是孕激素水平的改变可能具有调节作用。然而，在完整的动物中，明显地，睡莲只能降低FSH血清水平。

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