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AVICENNA ASPECT OF PREMATURE OVARIAN FAILURE

机译:卵巢早衰的AVICENNA方面

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Dear Editor, Estrogen deficiency in women is an important risk factor for serious disorders such as severe cardiovascular diseases (1). Several different conditions can lead to estrogen deficiency with premature ovarian failure (POF) being an important one (2, 3). POF includes the cessation of normal ovarian function before age 40, causing menopausal symptoms and general health problems. Although there are several known causes of ovarian failure i.e chromosomal defects, autoimmune disease, exposure to radiation and certain drugs: but most cases of POF are of unknown etiology. Consequently, further work is required to understand the etiology, possible prevention and treatment of POF (4). The most influential Iranian physician between 9th and 14th centuries AD was Ibn-Sina or Avicenna (980-1037 A.D). He was a great physician and has written more than 335 books on various subjects. His chief medical book is "Al-Qanon fi Al-Tibb" or "The Canon of Medicine" (5). According to "The Canon of Medicine", the basis of health is the right proportion and specific equilibrium of humors (Akhlat) according to their quality and quantity (6). Based on Iranian traditional medicine, there are four humors in the body: "Phlegm, Blood, Yellow bile and Black bile" (7). Each of them is related with a pair of qualities, including cold and wet, hot and wet, hot and dry, and cold and dry, respectively (6). In Iranian traditional medicine, premature ovarian failure is not defined the same as known today, but in many cases, it has been described as a disorder (8). Due to lack of biochemical analysis of blood parameters, almost all disease states have been defined based on clinical symptoms (9). The most obvious manifestation of POF is amenorrhea (10). The twenty-first chapter of third book of Al-Qanon fi Al-Tibb deals, principally with various kinds of uterine diseases. In this section, amenorrhea is described under a different title: "Ehtebase Tams" which means lack of menstruation. Avicenna has stated that one of the major causes of "Ehtebase tams" is abnormal black bile predominance (8). Based on The Canon of Medicine other symptoms that are seen in the "Ehtebase tams" of abnormal black bile predominance are as follows: vaginal dryness, dry eye, dry skin, anxiety, depression, somatization, sensitivity, hostility, forgetfulness, tiredness, headache, appetite disturbance, sleep disorder and depression and less satisfaction with sexual life (8). New studies have proven all of these symptoms (10). Black bile is divided into two categories: normal and abnormal. In contrast to normal black bile, abnormal black bile has affinity to deposit in any tissue and organ. As a consequence, in cases of abnormal black bile predominance, a high level of its deposition in the ovaries can lead to their dysfunction similar to its effect on other organs and tissues (arteries) (5, 7). According to this letter, it seems that the treatment of "black bile predominancea€? can be used as one of the first steps in treating POF patients. This finding can be used as an important theory to design the prevention and treatment plan of POF based on Iranian traditional medicine text books. Most obviously further clinical study is recommended to investigate this issue
机译:尊敬的编辑,女性的雌激素缺乏症是严重疾病(例如严重的心血管疾病)的重要危险因素(1)。几种不同的情况可以导致雌激素缺乏,卵巢早衰(POF)是重要的条件(2,3)。 POF包括在40岁之前停止正常的卵巢功能,导致更年期症状和一般健康问题。尽管有几种已知的卵巢功能衰竭原因,即染色体缺陷,自身免疫性疾病,暴露于放射线和某些药物;但是大多数POF病例的病因不明。因此,需要做进一步的工作来了解POF的病因,可能的预防和治疗方法(4)。在公元9至14世纪间,伊朗最有影响力的医生是伊本·西娜(Ibn-Sina)或阿维森纳(Avicenna)(公元980-1037年)。他是一位出色的医师,并且撰写了超过335本有关各个主题的书。他的主要医学著作是“ Al-Qanon fi Al-Tibb”或“ The Canon of Medicine”(5)。根据《医学佳能》,健康的基础是根据幽默的质量和数量确定正确比例和幽默的特定平衡(Akhlat)(6)。根据伊朗的传统医学,体内有四种幽默:“痰,血,黄胆和黑胆”(7)。它们中的每一个都具有一对特质,分别包括冷和湿,热和湿,热和干以及冷和干(6)。在伊朗传统医学中,卵巢早衰的定义与今天的定义不同,但在许多情况下,已将其描述为一种疾病(8)。由于缺乏血液参数的生化分析,几乎所有疾病状态都是根据临床症状定义的(9)。 POF最明显的表现是闭经(10)。 Al-Qanon fi Al-Tibb第三本书的第二十一章主要涉及各种子宫疾病。在本节中,闭经的另一个标题为:“ Ehtebase Tams”,这意味着月经不足。 Avicenna指出,“ Ehtebase tams”的主要原因之一是异常的黑胆汁占优势(8)。基于佳能医学,在“ Ehtebase tams”中发现的异常黑胆病占主导地位的其他症状如下:阴道干燥,干眼,皮肤干燥,焦虑,抑郁,躯体化,敏感,敌对,健忘,疲倦,头痛,食欲不振,睡眠障碍和抑郁,对性生活的满意度较低(8)。新的研究证明了所有这些症状(10)。黑胆分为两类:正常和异常。与正常的黑胆汁相反,异常的黑胆汁具有在任何组织和器官中沉积的亲和力。结果,在异常的黑胆汁占优势的情况下,其在卵巢中的高水平沉积可能导致其功能障碍,类似于其对其他器官和组织(动脉)的作用(5、7)。根据这封信,看来“黑胆病优势治疗”可以作为治疗POF患者的第一步,这一发现可以作为设计基于POF的预防和治疗计划的重要理论。有关伊朗传统医学教科书的文章,最明显的是,建议进行进一步的临床研究以调查此问题

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