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首页> 外文期刊>Iranian Journal of Reproductive Medicine >COMPARISON OF LEPTIN CONCENTRATIONS BETWEEN INFERTILE WOMEN WITH POLYCYSTIC OVARY SYNDROME AND FERTILE WOMEN; LETTER TO EDITOR
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COMPARISON OF LEPTIN CONCENTRATIONS BETWEEN INFERTILE WOMEN WITH POLYCYSTIC OVARY SYNDROME AND FERTILE WOMEN; LETTER TO EDITOR

机译：雌性多囊卵巢综合征与女性卵巢中瘦素浓度的比较致编辑

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Background: Some studies propose that changes in leptin concentrations (above or under the normal range) result in infertility. Therefore, we investigated serum and follicular fluid leptin concentrations in infertile women with polycystic ovary syndrome (PCOS).Objective: To study serum and follicular fluid leptin concentrations in infertile women with PCOS.Materials and Methods: We conducted a case-control study. The case group consisted of 30 infertile women with PCOS who were admitted to the Infertility Department of Imam Khomainy Hospital in Ahvaz, Iran. The control group consisted of 30 healthy fertile women adjusted for age and body mass index (BMI) with the case group. On day 14 of the menstrual cycle, 5 ml of blood was obtained from subjects in both groups. Serum and follicular fluid leptin concentrations were determined by the enzyme linked immunosorbent assay (ELISA). A Biovendor kit was used for the measurement of leptin concentrations. All data were analyzed using statistical package for the social sciences (SPSS) software (version 17.0, Nie, Bent & Hull, USA).Results: There was a significant correlation between BMI and serum leptin concentrations in both the control (p=0.005, r=0.516) and case groups (p=0.006, r=0.547). In the case group, serum leptin concentrations were consistent with follicular fluid leptin concentrations (p0.001, r=0.839). Comparison of serum leptin concentrations between the case and control groups revealed no significant difference (p=0.56).Conclusion: Infertility among women with PCOS was not a consequence of changes in leptin concentrations.
机译：背景：一些研究表明，瘦素浓度的变化（高于或低于正常范围）会导致不育。因此，我们调查了多囊卵巢综合征（PCOS）不育女性的血清和卵泡液瘦素浓度。目的：研究不育女性多囊卵巢综合征（PCOS）的血清和卵泡液瘦素浓度。材料与方法：我们进行了病例对照研究。该病例组由30名患有PCOS的不育女性组成，这些女性被送入伊朗阿瓦兹的伊玛目霍梅尼医院不育系。对照组由30名健康可育妇女组成，并根据病例组进行了年龄和体重指数（BMI）调整。在月经周期的第14天，两组受试者均获得了5 ml血液。通过酶联免疫吸附测定（ELISA）确定血清和卵泡液中的瘦素浓度。使用生物供应商试剂盒来测量瘦蛋白浓度。所有数据均使用社会科学（SPSS）软件（版本17.0，Nie，Bent＆Hull，美国）的统计软件包进行了分析。结果：两个对照组的BMI与血清瘦素浓度之间均存在显着相关性（p = 0.005， r = 0.516）和病例组（p = 0.006，r = 0.547）。在病例组中，血清瘦素浓度与卵泡液瘦素浓度一致（p <0.001，r = 0.839）。病例组和对照组之间的血清瘦素浓度比较无显着性差异（p = 0.56）。

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