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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Susceptibility to methamphetamine dependence associated with high transcriptional activity alleles of VNTR polymorphism in the promoter region of monoamine oxidase A (MAOA)
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Susceptibility to methamphetamine dependence associated with high transcriptional activity alleles of VNTR polymorphism in the promoter region of monoamine oxidase A (MAOA)

机译：单胺氧化酶A（ MAOA ）启动子区域中VNTR多态性高转录活性等位基因与甲基苯丙胺依赖性的敏感性

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Background and purpose Monoamine oxidase A (MAOA, Xp11.3; OMIM: 309850 ) can modulate the level of neurotransmitters in the central nervous system. A 30 bp variable number of tandem repeat (VNTR) genetic polymorphism on the promoter region of the MAOA can modulate the transcriptional activity of the gene. Association between this polymorphism and dependency to methamphetamine was investigated. Subjects and methods A total of 65 methamphetamine abusers (52 males and 13 females) and 635 healthy controls (525 males and 110 females) were included in the present case–control study. Genotypic analysis for the MAOA VNTR polymorphism was determined by conventional PCR. Based on transcriptional activity of the VNTR alleles, the alleles were categorized into two classes: L allele (2R and 3R alleles) and H allele (3.5R, 4R and 5R alleles), which have low and high transcriptional activities, respectively. Results Our data show that the H allele significantly increases the risk of methamphetamine dependence in males (OR = 2.03, 95% CI: 1.04–3.67, P = 0.037). The H allele seems positively associated with the risk of dependency to methamphetamine among females, but the observed OR did not reach the significance level, probability due to small sample size of the patients. Conclusion The present study supports the role of the VNTR polymorphism on the promoter region of the MAOA on methamphetamine dependence.
机译：背景和目的单胺氧化酶A（MAOA，Xp11.3; OMIM：309850）可以调节中枢神经系统中神经递质的水平。 MAOA的启动子区域的30 bp可变数目的串联重复序列（VNTR）遗传多态性可以调节基因的转录活性。研究了这种多态性与对甲基苯丙胺的依赖性之间的关联。对象和方法本病例对照研究共包括65名甲基苯丙胺滥用者（52名男性和13名女性）和635名健康对照（525名男性和110名女性）。通过常规PCR确定MAOA VNTR多态性的基因型分析。根据VNTR等位基因的转录活性，将等位基因分为两类：L等位基因（2R和3R等位基因）和H等位基因（3.5R，4R和5R等位基因），分别具有低和高转录活性。结果我们的数据显示，H等位基因显着增加了男性对甲基苯丙胺依赖的风险（OR = 2.03，95％CI：1.04-3.67，P = 0.037）。 H等位基因似乎与女性中依赖甲基苯丙胺的风险呈正相关，但由于患者样本量小，观察到的OR未达到显着性水平，即可能性。结论本研究支持VNTR多态性对甲基苯丙胺依赖性MAOA启动子区域的作用。

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