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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Role of TLR4 gene polymorphisms in the colorectal cancer risk modulation in ethnic Kashmiri population – A case–control study
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Role of TLR4 gene polymorphisms in the colorectal cancer risk modulation in ethnic Kashmiri population – A case–control study

机译： TLR4 基因多态性在克什米尔族人群结直肠癌风险调控中的作用–病例对照研究

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Background Colorectal carcinogenesis has been found to be associated with the polymorphic status of Toll-like receptor 4 gene in various populations of the world. Aim The aim of the study was to determine the genetic association of TLR4 gene polymorphisms (Asp299Gly and Thr399Ile) with disease susceptibility and risk development in colorectal cancer (CRC) patients of Kashmir, India. Materials and methods Genotype frequencies of TLR4 polymorphisms (Asp299Gly and Thr399Ile) were compared between 120 CRC patients and 200 healthy controls using PCR-RFLP method. Results We did not find any significant association between the TLR4 gene polymorphisms and the CRC cases ( p 0.05). However CT genotype (Thr399Ile) showed modest elevated risk of the development of CRC [OR = 1.78 95% CI (0.88–3.5)]. Also G allele (AG genotype) of TLR-4 Asp299Gly polymorphism was found to be significantly associated with the male gender ( p value = 0.006) and involvement of Nodes ( p value = 0.01) whereas, T allele (CT genotype) of Thr399Ile polymorphism showed significant association with the smoking status ( p value = 0.03). Conclusion Our results suggest that TLR4 gene polymorphism is not a key modulator of the risk of developing colorectal cancer in Kashmiri population.
机译：背景技术已发现在世界各地的人群中，结直肠癌的发生与Toll样受体4基因的多态性有关。目的本研究的目的是确定印度克什米尔大肠癌（CRC）患者中TLR4基因多态性（Asp299Gly和Thr399Ile）与疾病易感性和风险发展的遗传关联。材料和方法使用PCR-RFLP方法比较了120例CRC患者和200例健康对照的TLR4基因多态性（Asp299Gly和Thr399Ile）的基因型频率。结果我们没有发现TLR4基因多态性与CRC病例之间存在显着相关性（p> 0.05）。然而，CT基因型（Thr399Ile）显示出发生CRC的风险适度升高[OR = 1.78 95％CI（0.88-3.5）]。还发现TLR-4 Asp299Gly多态性的G等位基因（AG基因型）与男性（p值= 0.006）和淋巴结的参与（p值= 0.01）显着相关，而Thr399Ile多态性的T等位基因（CT基因型）表现出与吸烟状态显着相关（p值= 0.03）。结论我们的结果表明，TLR4基因多态性不是克什米尔人群中发展结直肠癌风险的关键调节因子。

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