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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Cytogenetical analysis in blood lymphocytes of cigarette smokers in Tiruchirappalli district, Tamil Nadu, India
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Cytogenetical analysis in blood lymphocytes of cigarette smokers in Tiruchirappalli district, Tamil Nadu, India

机译：印度泰米尔纳德邦蒂鲁吉拉伯利地区吸烟者血液淋巴细胞的细胞遗传学分析

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Background Tobacco smoke causes serious health ill effects to human population. Cancer and cardiovascular diseases are more common in smoking subjects. Aim The present study is focused about the genetical changes in smoking subjects based on their age and pack years. Subjects and methods Based on a survey report, 160 subjects are selected from Tiruchirappalli district, Tamil Nadu, India. Venous blood and buccal smear samples are collected from each subject. Results Increased CA is observed in heavy smokers compared to light and non smokers which is 8.90 ± 2.58, 4.58 ± 2.36 and 4.31 ± 1.17, respectively. Both medium and light smokers showed significantly increased CA frequencies than control. Comet assay showed increased percentage of abnormalities in smokers (light, medium and heavy) than non-smokers. Conclusion The frequencies of MN in buccal epithelial and blood lymphocytes are high in smokers; particularly heavy smoker group showed significantly increased results. Among them, the lymphocytic cells showed high MN frequency.
机译：背景技术烟草烟雾对人类造成严重的健康危害。吸烟者中癌症和心血管疾病更为常见。目的本研究的重点是根据吸烟者的年龄和包装年限对其遗传变化进行研究。受试者和方法根据一份调查报告，从印度泰米尔纳德邦的蒂鲁吉拉伯利地区选出160名受试者。从每个受试者收集静脉血液和颊涂片样品。结果与轻和不吸烟者相比，重度吸烟者CA升高，分别为8.90±2.58、4.58±2.36和4.31±1.17。中度和轻度吸烟者的CA频率均显着高于对照组。彗星试验显示，吸烟者（轻度，中度和重度）的异常率比非吸烟者高。结论吸烟者颊上皮和血液淋巴细胞的MN发生率高;特别是重度吸烟者组的结果显着增加。其中，淋巴细胞显示出高的MN频率。

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