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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Evaluation of the association of single nucleotide polymorphisms in DDP4 and CDK5RAP2 genes with rheumatoid arthritis susceptibility in Iranian population
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Evaluation of the association of single nucleotide polymorphisms in DDP4 and CDK5RAP2 genes with rheumatoid arthritis susceptibility in Iranian population

机译：伊朗人群中DDP4和CDK5RAP2基因单核苷酸多态性与类风湿关节炎易感性的关系评估

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Background Rheumatoid arthritis (RA) is known as a chronic autoimmune inflammatory disorder, which is characterized mainly by the progressive inflammation and destruction of the joints. In the pathogenesis of RA, a variety of cell types such as lymphocyte, dendritic cells, osteoclasts and synovial fibroblasts are involved. Genetic proneness has been implicated in the pathogenesis of RA. The aim of this study was to evaluate the association of single nucleotide polymorphisms (SNPs) in DPP4 and CDK5RAP2 genes and risk of RA in Iranian population. Methods For genotyping, 623 RA patients and 412 healthy subjects were recruited. Genetic analysis of DPP4 gene rs12617656 and CDK5RAP2 gene rs12379034 polymorphisms was conducted using TaqMan allelic discrimination (for rs12617656) and ARMS-PCR (for rs12379034) methods. Results Experiments demonstrated that alleles and genotypes of both SNPs were represented equally in RA patients and controls. Statistical analysis revealed that none of the rs12617656 and rs12379034SNPs had significant differences in prevalence of both alleles and genotypes between RA patients and healthy controls. Conclusions It appears that gene polymorphisms of DPP4 and CDK5RAP2 are not involved in the pathogenesis of RA in Iranian population.
机译：背景类风湿关节炎（RA）被称为慢性自身免疫性炎症性疾病，其主要特征是进行性炎症和关节破坏。在RA的发病机理中，涉及多种细胞类型，例如淋巴细胞，树突状细胞，破骨细胞和滑膜成纤维细胞。遗传倾向与RA的发病机制有关。这项研究的目的是评估DPP4和CDK5RAP2基因中的单核苷酸多态性（SNP）与伊朗人群RA的风险之间的关系。方法对623名RA患者和412名健康受试者进行基因分型。 DPP4基因rs12617656和CDK5RAP2基因rs12379034多态性的遗传分析使用TaqMan等位基因鉴别（针对rs12617656）和ARMS-PCR（针对rs12379034）进行。结果实验表明，RA患者和对照中两种SNP的等位基因和基因型均相等。统计分析显示，rs12617656和rs12379034SNP在RA患者与健康对照组之间，等位基因和基因型的患病率均无显着差异。结论DPP4和CDK5RAP2基因多态性似乎与伊朗人群RA的发病机制无关。

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