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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Association between the polymorphisms of matrix metalloproteinases 9 and 3 genes and risk of myocardial infarction in Egyptian patients
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Association between the polymorphisms of matrix metalloproteinases 9 and 3 genes and risk of myocardial infarction in Egyptian patients

机译：埃及患者基质金属蛋白酶9和3基因多态性与心肌梗死风险的关系

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The present study investigated the relationship between the genetic polymorphisms in MMP-9 and MMP-3 genes and acute myocardial infarction (AMI). We examined 40 patients with acute myocardial infarction and 40 age and sex matched controls for MMP-9 functional promoter polymorphism (?1562 C>T) and MMP-3 (5A/6A) deletion/insertion polymorphism using restriction fragment length polymorphism (RFLP) for amplified genomic DNA. The frequencies of the combined mutant genotypes CT and TT in the (?1562 C>T) MMP9 were significantly higher in AMI patients (20%) when compared to the controls (0%) ( p value=0.005) showing an association between these genotypes and AMI. Also there was a significant difference between 5A/5A genotype and 5A allele frequencies when both are compared in the patients (25% and 35%) and the controls (2.5% and 18.75%) ( p =0.009; OR=13; CI=1.576–107.233); and ( p =0.02; OR=2.333, CI=1.130–4.820) respectively. In conclusion, the ?1562C>T polymorphism of the MMP9 gene is strongly associated with acute myocardial infarction in the Egyptian population. Furthermore, our study supported the presence of the 5A/5A genotype of MMP3 gene promoter polymorphism as a risk factor of AMI in Egyptian patients. Meanwhile, the race selection should be paid more attention since the pathogenesis of a disease might have different bases in different racial population groups.
机译：本研究调查了MMP-9和MMP-3基因的遗传多态性与急性心肌梗死（AMI）之间的关系。我们使用限制性片段长度多态性（RFLP）检查了40例急性心肌梗塞和40例年龄和性别相匹配的MMP-9功能启动子多态性（？1562 C> T）和MMP-3（5A / 6A）缺失/插入多态性的对照。用于扩增的基因组DNA。与对照组（0％）相比，AMI患者（？1562 C> T）MMP9中组合突变基因型CT和TT的频率（20％）显着更高（p值= 0.005），表明两者之间存在关联基因型和AMI。当在患者（25％和35％）和对照组（2.5％和18.75％）中进行比较时，在5A / 5A基因型和5A等位基因频率之间也存在显着差异（p = 0.009; OR = 13; CI = 1.576–107.233）;和（p = 0.02; OR = 2.333，CI = 1.130-4.820）。总之，埃及人群中MMP9基因的？1562C> T多态性与急性心肌梗塞密切相关。此外，我们的研究支持存在MMP3基因启动子多态性的5A / 5A基因型作为埃及患者AMI的危险因素。同时，由于疾病的发病机理在不同种族人群中可能具有不同的基础，因此应该更加注意种族的选择。

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