...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Iranian red crescent medical journal >Crucial Roles of Systemic and Tissue Lipid Peroxidation Levels and Anti-Oxidant Defences Following Contrast Agent Application
【24h】

Crucial Roles of Systemic and Tissue Lipid Peroxidation Levels and Anti-Oxidant Defences Following Contrast Agent Application

机译：应用造影剂后全身和组织脂质过氧化水平和抗氧化剂防御的关键作用

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

One of the most important side effects of contrast pharmaceutical agents, which are used very common in routine radiology practice, is contrast induced nephropathy. Even ischemia, oxidative stress and osmolality related cytotoxic effects are considered, the molecular mechanisms underlying this pathology have not been identified completely yet. Objectives: The aim of the current study was to reveal the role of oxidative stress and antioxidant enzymatic defence mechanisms in the aetiopathogenesis of contrast-induced nephropathy. We also studied possible alleviating effects of N-acetylcysteine (NAC), a potent antioxidant, to obtain extra information regarding the molecular mechanisms underlying this pathology. Materials and Methods: This is an clinical-experimental study, This study was conducted of Istanbul/Turkey between September 15, 2012 and April 15, 2013. Three groups of male rats were randomly set up as a control group (C), a 100 mg/kg intraperitoneal NAC + 7 mL/kg contrast agent group (N + CIN) and a 7 mL/kg intraperitoneal contrast agent group (CIN). They were placed in individual metabolic cages 48 hours after agent administration to obtain 24-hour urine samples. Renal function tests (albumin, urea, creatinine, total protein) were conducted, oxidative stress parameters (Cu, Zn superoxide dismutase activity - Cu, Zn-SOD; advanced oxidation protein products - AOPP; protein carbonyls - PCO; total thiol groups - T-SH; and lipid hydroperoxides -LHP) were measured and tissues were analysed histopathologically. Results: Compared with the control group, groups CIN and N + CIN had significantly higher urea and LHP levels (P < 0.05 and P < 0.001, respectively) and significantly lower Cu, Zn-SOD activity and creatinine clearance (P < 0.05). There was no statistically significant difference between the groups in PCO or AOPP levels despite differences in descriptive statistics. Conclusions: Contrast-agent-induced nephropathic changes are more closely related to the magnitude of lipid peroxidation than protein oxidation.
机译：造影剂引起的肾病是在常规放射学实践中非常普遍使用的造影剂最重要的副作用之一。即使考虑到缺血，氧化应激和重量摩尔渗透压浓度相关的细胞毒性作用，这种病理的潜在分子机制尚未完全确定。目的：本研究的目的是揭示氧化应激和抗氧化酶防御机制在造影剂诱发的肾病的发病机制中的作用。我们还研究了可能有效的抗氧化剂N-乙酰半胱氨酸（NAC）的缓解作用，以获得有关此病理基础分子机制的额外信息。材料和方法：这是一项临床实验研究，该研究于2012年9月15日至2013年4月15日在伊斯坦布尔/土耳其进行。将三组雄性大鼠随机分为对照组（C），每组100只。 mg / kg腹膜内NAC + 7 mL / kg造影剂组（N + CIN）和7 mL / kg腹膜内造影剂组（CIN）。给药后48小时将它们放在单独的代谢笼中，以获得24小时尿液样本。进行肾功能测试（白蛋白，尿素，肌酐，总蛋白），氧化应激参数（Cu，Zn超氧化物歧化酶活性-Cu，Zn-SOD;高级氧化蛋白产物-AOPP;蛋白羰基-PCO;总硫醇基-T -SH;和脂质氢过氧化物-LHP）被测量和组织进行了组织病理学分析。结果：与对照组相比，CIN组和N + CIN组的尿素和LHP水平明显升高（分别为P <0.05和P <0.001），而Cu，Zn-SOD活性和肌酐清除率则显着降低（P <0.05）。尽管描述性统计上存在差异，但两组之间的PCO或AOPP水平在统计学上没有显着差异。结论：造影剂引起的肾病性改变与脂质过氧化的程度比蛋白质氧化更密切相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号