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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Apelin rs2235306 polymorphism is not related to metabolic syndrome in Egyptian women
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Apelin rs2235306 polymorphism is not related to metabolic syndrome in Egyptian women

机译：Apelin rs2235306多态性与埃及女性的代谢综合征无关

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Background Apelin is an adipokine that was identified to play a role in the control of glucose homeostasis. Apelin rs2235306 gene polymorphism was linked to insulin resistance and poor glycemic control. Aim of the study To assess the relation of apelin rs2235306 polymorphism with metabolic syndrome and its component traits in Egyptian women from Suez Canal area. Subjects and methods The study included 100 metabolic syndrome patients and 100 healthy female subjects. The component traits of metabolic syndrome were determined and the genotypes of the polymorphisms were assessed using tetra amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR) technique. Results There was no significant difference in the allele frequencies between the metabolic syndrome and control groups ( P =0.841). There was also no association of the different genotypes of this polymorphism with any of the component traits of metabolic syndrome. Conclusion Apelin rs2235306 polymorphism is not associated with the incidence of metabolic syndrome in the studied population.
机译：背景Apelin是一种脂肪因子，已被确定在控制葡萄糖稳态中发挥作用。 Apelin rs2235306基因多态性与胰岛素抵抗和不良的血糖控制有关。研究的目的是评估苏伊士运河地区埃及妇女的apelin rs2235306多态性与代谢综合征及其组成特征的关系。受试者和方法该研究包括100名代谢综合征患者和100名健康女性受试者。使用四扩增难治性突变系统聚合酶链反应（T-ARMS-PCR）技术确定代谢综合征的组成特征，并评估多态性的基因型。结果代谢综合征与对照组之间的等位基因频率无显着差异（P = 0.841）。该多态性的不同基因型与代谢综合征的任何组成特征也没有关联。结论Apelin rs2235306基因多态性与研究人群代谢综合征的发生率无关。

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