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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >An overview on hepatitis C virus genotypes and its control
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An overview on hepatitis C virus genotypes and its control

机译：丙型肝炎病毒基因型及其控制概述

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Hepatitis C virus (HCV) is a blood borne, circular and positive single stranded virus with high spread rates. With the passage of time the frequency of HCV is increasing in different parts of the world. HCV is a major cause, which may end in liver cirrhosis and hepatocellular carcinoma. HCV has six main genotypes with many subtypes, which have variable sequence homology with each other. Symptoms can appear anytime from 2 weeks to 6 months, which include jaundice, fatigue, gray-colored stool, joint pain, belly pain, weakness, anorexia, itchy skin and dark urine. Genotyping is more significant for planning of HCV treatment period and helps to cure HCV infections. For the quantification and identification of hepatitis C virus-ribonucleic acid, many molecular techniques are performed; the most significant are HCV ELISA, quantitative HCV-RNA PCR and recombinant immunoblot assay. PCR is the major technique targeting 5′ untranslated region (UTR). HCV can be transmitted by contaminated blood, ear and nose piercing and contaminated medical instruments. To overcome the rate of HCV, guidance should be provided to make aware the persons about risk factors, transmission and prevention. Discovery and designing of new therapies and vaccines to overcome this disease are the necessity of the present era. Four types of vaccines such as vector vaccines, peptide vaccines, DNA vaccines and recombinant protein vaccines are available in clinical trials.
机译：丙型肝炎病毒（HCV）是一种血液传播的环状和阳性单链病毒，具有很高的传播率。随着时间的流逝，HCV的频率在世界各地有所增加。 HCV是主要病因，可能以肝硬化和肝细胞癌结束。 HCV有六个主要的基因型，其中有许多亚型，它们彼此之间具有可变的序列同源性。从2周到6个月中的任何时间均可出现症状，包括黄疸，疲劳，粪便呈灰色，关节痛，腹痛，无力，厌食，皮肤发痒和尿液发黑。基因分型对于HCV治疗期的规划更为重要，有助于治愈HCV感染。为了定量和鉴定丙型肝炎病毒-核糖核酸，进行了许多分子技术研究。最重要的是HCV ELISA，定量HCV-RNA PCR和重组免疫印迹测定。 PCR是靶向5'非翻译区（UTR）的主要技术。 HCV可以通过被污染的血液，耳鼻孔和被污染的医疗器械传播。为了克服HCV的发生率，应提供指导以使人们了解危险因素，传播和预防。发现和设计克服这种疾病的新疗法和疫苗是当今时代的必要。临床试验中可使用四种类型的疫苗，例如载体疫苗，肽疫苗，DNA疫苗和重组蛋白疫苗。

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