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首页> 外文期刊>Iranian red crescent medical journal >Longitudinal Discriminant Analysis of Hemoglobin Level for Predicting Preeclampsia
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Longitudinal Discriminant Analysis of Hemoglobin Level for Predicting Preeclampsia

机译：血红蛋白水平的纵向判别分析预测先兆子痫

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Preeclampsia is one of the most serious complications during pregnancy with important effects on health of mother and fetus that causes maternal and fetal morbidity and mortality. This study was performed to evaluate whether high levels of hemoglobin may increase the risk of preeclampsia. Objectives: The present study aimed to predict preeclampsia by the hemoglobin profiles through longitudinal discriminant analysis and comparing the error rate of discrimination in longitudinal and cross sectional data. Patients and Methods: In a prospective cohort study from October 2010 to July 2011, 650 pregnant women referred to the prenatal clinic of Milad Hospital in Tehran were evaluated in 3 stages. The hemoglobin level of each woman was measured in the first, second, and third trimester of pregnancy by an expert technician. The subjects were followed up to delivery and preeclampsia was the main outcome under study. The covariance pattern and linear-mixed effects models are common methods that were applied for discriminant analysis of longitudinal data. Also Student t, Mann-Whitney U, and chi-square tests were used for comparing the demographic and clinical characteristics between two groups. Statistical analyses were performed using the SAS software version 9.1. Results: The prevalence rate of preeclampsia was 7.2% (47 women). The women with preeclampsia had a higher mean of hemoglobin values and the difference was 0.46 g/dL (P = 0.003). Also the mean of hemoglobin in the first trimester was higher than that of the second trimester, and was lower than that of the third trimester and the differences were significant (P = 0.015 and P < 0.001, respectively). The sensitivity for longitudinal data and cross-sectional data in three trimesters was 90%, 67%, 72%, and 54% and the specificity was 88%, 55%, 63%, and 50%, respectively. Conclusions: The levels of hemoglobin can be used to predict preeclampsia and monitoring the pregnant women and its regular measure in 3 trimesters help us to identify women at risk for preeclampsia.
机译：子痫前症是怀孕期间最严重的并发症之一，对母亲和胎儿的健康具有重要影响，会引起母婴发病率和死亡率。进行这项研究是为了评估高水平的血红蛋白是否会增加先兆子痫的风险。目的：本研究旨在通过纵向判别分析通过血红蛋白曲线预测先兆子痫，并比较纵向和横截面数据中的判别错误率。患者和方法：在2010年10月至2011年7月的一项前瞻性队列研究中，分3个阶段对650名转诊至德黑兰Milad医院产前诊所的孕妇进行了评估。在怀孕的第一，第二和第三个月，由专业技术人员测量每个妇女的血红蛋白水平。对受试者进行分娩，先兆子痫是研究的主要结果。协方差模式和线性混合效应模型是用于对纵向数据进行判别分析的常用方法。另外，使用Student t，Mann-Whitney U和卡方检验来比较两组的人口统计学和临床​​特征。使用SAS软件9.1版进行统计分析。结果：先兆子痫的患病率为7.2％（47名妇女）。子痫前期妇女的血红蛋白平均值较高，差异为0.46 g / dL（P = 0.003）。另外，妊娠中期的血红蛋白平均值高于妊娠中期的平均值，低于妊娠中期的平均值，差异有统计学意义（分别为P = 0.015和P <0.001）。三个中期的纵向数据和横截面数据的敏感性分别为90％，67％，72％和54％，特异性分别为88％，55％，63％和50％。结论：血红蛋白水平可用于预测先兆子痫和监测孕妇，并且在三个月的常规测量有助于我们识别处于先兆子痫风险的妇女。

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