...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Serum amino acid abnormalities in pediatric patients with chronic renal failure with and without history of thromboembolic manifestations
【24h】

Serum amino acid abnormalities in pediatric patients with chronic renal failure with and without history of thromboembolic manifestations

机译：有和没有血栓栓塞表现史的慢性肾功能衰竭儿科患者的血清氨基酸异常

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Plasma amino acid concentrations have been reported to be abnormal in patients with chronic renal failure. l -Arginine has been used to improve endothelial function by increasing nitric oxide (NO) bioavailability. The present study aim at investigating the status of plasma amino acids in pediatric patients with chronic renal failure (CRF) on regular hemodialysis (HD) with and without history of thromboembolic manifestations. Methods The study included 21 hemodialysis patients subdivided into two groups (those with no history of thromboembolic manifestations and those with positive history of thromboembolic manifestations) The control group included 13 age and sex matched apparently healthy subjects, After careful history taking, clinical examination, the following laboratory investigations were performed: serum calcium, phosphate, albumin, and creatinine (for controls only), complete blood count (CBC) and serum amino acid analysis. Results HD patients had a significantly lower concentration of threonine, valine, methionine, leucine, tyrosine, phenylalanine and tryptophane than the control group ( p =0.032, 0.020, 0.046, 0.011, 0.000, 0.022, and 0.004 respectively). There was no significant difference between HD patients and the control group as regard aspartic acid, serine, asparagine, glutamic acid, proline, glycine, alanine, cystine, isoleucine, lysine, histidine, and arginine. The mean serum l -arginine level was lower in 61.9% of HD patients than the mean of the controls with no significant difference. l -Arginine concentration was not significantly different between HD patients with and without history of thromboembolic manifestations. Conclusion Several abnormalities in amino acids were present in HD patients compared to controls. The mean serum l -arginine level was lower in 61.9% of HD patients than the mean of the controls with no significant difference. l -Arginine concentration was not significantly different between HD patients with and without history of thromboembolic manifestations. HD patients without history of thromboembolic manifestations had significantly lower glutamic acid concentrations and significantly higher phenylalanine concentrations than HD patients with history of thromboembolic manifestations.
机译：背景技术据报道，患有慢性肾功能衰竭的患者血浆氨基酸浓度异常。 1-精氨酸已被用于通过增加一氧化氮（NO）的生物利用度来改善内皮功能。本研究旨在调查有无血栓栓塞表现史的定期血液透析（HD）患儿慢性肾功能衰竭（CRF）患儿血浆氨基酸的状况。方法该研究包括21例血液透析患者，分为两组（无血栓栓塞表现史和血栓栓塞表现史阳性者），对照组包括13名年龄和性别相匹配的明显健康受试者，经过仔细的病史记录，临床检查，进行了以下实验室检查：血清钙，磷酸盐，白蛋白和肌酐（仅用于对照），全血细胞计数（CBC）和血清氨基酸分析。结果HD患者的苏氨酸，缬氨酸，蛋氨酸，亮氨酸，酪氨酸，苯丙氨酸和色氨酸的浓度均显着低于对照组（分别为p = 0.032、0.020、0.046、0.011、0.000、0.022和0.004）。 HD患者与对照组在天冬氨酸，丝氨酸，天冬酰胺，谷氨酸，脯氨酸，甘氨酸，丙氨酸，胱氨酸，异亮氨酸，赖氨酸，组氨酸和精氨酸方面无显着差异。 HD患者中61.9％的平均血清l-精氨酸水平低于对照组的平均值，无显着差异。有和没有血栓栓塞表现史的HD患者之间的1-精氨酸浓度无显着差异。结论与对照组相比，HD患者存在一些氨基酸异常。 HD患者中61.9％的平均血清l-精氨酸水平低于对照组的平均值，无显着差异。有和没有血栓栓塞表现史的HD患者之间的1-精氨酸浓度无显着差异。没有血栓栓塞表现史的HD患者比有血栓栓塞表现史的HD患者的谷氨酸浓度明显降低，苯丙氨酸浓度显着升高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号