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首页> 外文期刊>International Journal of Medicine and Medical Sciences >A survey of hepatitis B and C virus prevalence in human immunodeficiency virus positive patients in a tertiary health institution in North Eastern Nigeria
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A survey of hepatitis B and C virus prevalence in human immunodeficiency virus positive patients in a tertiary health institution in North Eastern Nigeria

机译：尼日利亚东北部一家三级医疗机构中人类免疫缺陷病毒阳性患者的乙型和丙型肝炎病毒流行情况调查

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  Co-infection of hepatotropic virus(es), with HIV has been associated with a reduced survival rate, an increased risk of progression to severe liver disease, and an increased risk of hepatotoxicity associated with active antiretroviral therapy. Information regarding prevalence of HBV and HCV co-infection with HIV in Nigeria is limited. This study was designed to determine the seroprevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV), and the impact of co-infection on baseline serum alanine transaminase (ALT), CD4+ T lymphocyte (CD4) count, and plasma HIV-RNA (viral load) in a cohort of HIV-infected Nigerians. Patients confirmed to be positive for HIV infection by Western blot analysis were consecutively recruited into the study from Infectious Disease Clinic, General Out-patient Department and Medical Wards of University of Maiduguri Teaching Hospital, Nigeria. Demographic data and pre-treatment laboratory results (hepatitis B surface antigen (HBsAg), and HCV antibodies (anti-HCV), ALT, CD4 count and viral load) were analysed. A total of 569 HIV-infected patients (male: female ratio, 1:1.4) were consecutively recruited. HBsAg was present in 12.3%; anti- HCV in 0.5% and both markers was not present in any patients. HBsAg prevalence was 12.3% in both male and females, while anti-HCV was detected in 0.8% in males and 0.3% females. HIV-infected patients alone had a higher mean baseline CD4 count compared to those without anti- HCV or HBsAg (181 vs. 117 cells/mm3, respectively; p = 0.01). Serum ALT was higher among patients co-infected with HBsAg or anti-HCV than only HIV infected (37 vs. 34 International Units (IU), respectively p = 0.1). The high frequency of HBsAg confirms the need for routine screening for these markers in HIV-infected patients in our setting. CD4 count was significantly lower, in patients with prior exposure to hepatitis B or C, while ALT was slightly higher among those positive for HBV or C infection. These findings are pointer to the importance of testing for HBV and HCV in all HIV-infected persons in our setting.  
机译：肝炎病毒与HIV的共同感染与存活率降低，发展为严重肝病的风险增加以及积极抗逆转录病毒疗法相关的肝毒性风险增加有关。关于尼日利亚的HBV和HCV合并感染HIV患病率的信息有限。本研究旨在确定乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的血清阳性率，以及共感染对基线血清丙氨酸转氨酶（ALT），CD4 + T淋巴细胞（CD4）计数和血浆HIV的影响-一群被HIV感染的尼日利亚人中的RNA（病毒载量）。通过Western blot分析确定为HIV感染阳性的患者被连续招募至尼日利亚梅杜古里大学教学医院的传染病诊所，普通门诊部和医学病房。分析了人口统计学数据和治疗前的实验室结果（乙肝表面抗原（HBsAg）和HCV抗体（抗HCV），ALT，CD4计数和病毒载量）。连续招募了569名HIV感染患者（男性与女性的比例为1：1.4）。 HBsAg的含量为12.3％;抗HCV的比例为0.5％，两种标志物均未出现在任何患者中。男性和女性的HBsAg患病率均为12.3％，而男性和女性的抗HCV检出率分别为0.8％和0.3％。与没有抗HCV或HBsAg的患者相比，仅HIV感染的患者的平均基线CD4计数更高（分别为181 vs. 117细胞/ mm3; p = 0.01）。在合并感染HBsAg或抗HCV的患者中，血清ALT高于仅感染HIV的患者（37 vs. 34国际单位（IU），分别为p = 0.1）。 HBsAg的高频率证实了在我们的环境中需要常规筛查HIV感染患者的这些标志物。在先前接触过乙型或丙型肝炎的患者中，CD4计数显着降低，而在HBV或C型感染阳性的患者中ALT略高。这些发现表明，在我们的环境中，对所有HIV感染者进行HBV和HCV检测的重要性。

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