Scientific Opinion on the substantiation of health claims related to various microorganisms and reduction of gastro‐intestinal discomfort (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970), decreasing potentially pathogenic gastro‐intestinal microorganisms (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970), improved lactose digestion (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970), “intestinal flora/digestive health” (ID 4231), defence against vaginal pathogens (ID 2950, 2957, 2967) and increasing IL‐10 production and/or enhancing the activity of natural killer cells (ID 2960, 2962, 2971) (further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

首页> 外文期刊>EFSA Journal >Scientific Opinion on the substantiation of health claims related to various microorganisms and reduction of gastro‐intestinal discomfort (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970), decreasing potentially pathogenic gastro‐intestinal microorganisms (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970), improved lactose digestion (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970), “intestinal flora/digestive health” (ID 4231), defence against vaginal pathogens (ID 2950, 2957, 2967) and increasing IL‐10 production and/or enhancing the activity of natural killer cells (ID 2960, 2962, 2971) (further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

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Scientific Opinion on the substantiation of health claims related to various microorganisms and reduction of gastro‐intestinal discomfort (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970), decreasing potentially pathogenic gastro‐intestinal microorganisms (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970), improved lactose digestion (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970), “intestinal flora/digestive health” (ID 4231), defence against vaginal pathogens (ID 2950, 2957, 2967) and increasing IL‐10 production and/or enhancing the activity of natural killer cells (ID 2960, 2962, 2971) (further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

机译：关于证实与各种微生物有关的健康主张并减少肠胃不适的科学意见（ID 1030、2956、2958、2961、2963、2966、2970），减少了潜在致病性的肠胃微生物（ID 1030、2956、2958），2961、2963、2966、2970），改善的乳糖消化（ID 1030、2956、2958、2961、2963、2966、2970），“肠道菌群/消化系统健康”（ID 4231），防御阴道病原体（ID 2950，（2957、2967）和增加IL-10的产生和/或增强自然杀伤细胞的活性（ID 2960、2962、2971）（进一步评估），符合（EC）第1924/2006号法规第13（1）条

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Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to provide a scientific opinion on health claims pursuant to Article 13 of Regulation (EC) No 1924/2006 in the framework of further assessment related to various microorganisms and reduction of gastro‐intestinal discomfort, decreasing potentially pathogenic gastro‐intestinal microorganisms, improved lactose digestion, “intestinal flora/digestive health”, defence against vaginal pathogens and increasing IL‐10 production and/or enhancing the activity of natural killer cells. The food constituents Lactobacillus crispatus BCCM/LMG P‐17631, Lactobacillus gasseri BCCM/LMG P‐17632, Lactobacillus gasseri BCCM/LMG P‐18137, Lactobacillus paracasei CNCM I‐1687, Lactobacillus paracasei CNCM I‐1688, Lactobacillus plantarum BCCM/LMG P‐17630, Lactobacillus salivarius CNCM I‐1794 and a combination of Bifidobacterium animalis ssp. lactis Bf‐6 and Lactobacillus johnsonii La‐1 (ACD‐1)(CLbA22) are sufficiently characterised. The evidence provided did not establish that the proposed claimed effect, increasing IL‐10 production and/or enhancing the activity of natural killer cells, is a beneficial physiological effect. The claimed effect “intestinal flora/digestive health” is general and non‐specific, and does not refer to any specific health claim as required by Regulation (EC) No 1924/2006. The references provided in relation to the claims evaluated in this opinion included studies which assessed the effects of food constituents other than the food constituents which are the subject of the claims and/or investigated health outcomes unrelated to the claimed effects. No human studies which investigated the effects of the food constituents on appropriate measures of the claimed effects were provided. On the basis of the data presented, the Panel concludes that a cause and effect relationship has not been established between the consumption of the food constituents and the claimed effects evaluated in this opinion.

机译：应欧洲委员会的要求，要求营养产品，营养和过敏问题专家组（NDA）根据与欧盟有关的进一步评估框架，根据1924/2006号法规（EC）第13条，就健康声明提供科学意见。各种微生物，减少肠胃不适，减少潜在的致病性肠胃微生物，改善乳糖消化，“肠道菌群/消化健康”，防御阴道病原体，增加IL-10的产生和/或增强自然杀手的活性细胞。食品成分cristableatus BCCM / LMG P-17631，gasseri gasseri BCCM / LMG p-17632，gasseri gasseri BCCM / LMG P-18137，paracasei干酪乳杆菌CNCM I-1687，paracasei干酪乳杆菌CNCM I-1688LM，LactoBCillus植物-17630，唾液乳杆菌CNCM I-1794和动物双歧杆菌ssp的组合。乳酸Bf-6和约翰逊乳杆菌La-1（ACD-1）（CLbA22）具有足够的特征。所提供的证据并未证明所提议的效应，增加IL-10的产生和/或增强自然杀伤细胞的活性是有益的生理效应。所声称的“肠道菌群/消化系统健康”效应是一般性且非特异性的，并不涉及法规（EC）1924/2006号所要求的任何特定的健康声称。关于在此意见中评估的权利要求所提供的参考文献包括研究，这些研究评估了除权利要求所涉及的食物成分以外的食物成分的影响和/或调查了与要求的影响无关的健康结果。没有提供任何人类研究来调查食品成分对要求的影响的适当措施的影响。根据提供的数据，小组得出结论认为，在食品成分的消费与该意见所评价的所称效果之间尚未建立因果关系。

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《EFSA Journal》 |2012年第8期|共34页
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1. Scientific Opinion on the substantiation of health claims related to a combination of Lactobacillus paracasei CNCM I‐1688 and Lactobacillus salivarius CNCM I‐1794 and reduction of gastro‐intestinal discomfort (ID 2972), decreasing potentially pathogenic gastro‐intestinal microorganisms (ID 2972), improved lactose digestion (ID 2972) and increasing IL‐10 production (ID 2973) (further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [J] . EFSA Journal . 2012,第8期

机译：关于证实与副干酪乳杆菌CNCM I-1688和唾液乳杆菌CNCM I-1794联合使用和减少胃肠道不适（ID 2972），减少潜在致病性胃肠道微生物（ID 2972）有关的健康主张的科学意见，根据1924/2006号法规（EC）第13（1）条，改善了乳糖消化（ID 2972）并提高了IL-10产量（ID 2973）（进一步评估）
2. Scientific Opinion on the substantiation of health claims related to a combination of Lactobacillus acidophilus BCCM/LMG P‐18806, Lactobacillus delbrueckii BCCM/LMG P‐18805 and Streptococcus thermophilus BCCM/LMG P‐18807 and reduction of gastro‐intestinal discomfort (ID 2946, 2951, 2974), decreasing potentially pathogenic gastro‐intestinal microorganisms (ID 2946, 2951, 2974), improved lactose digestion (ID 2946, 2951, 2974), and reduction in numbers of circulating CD34+ cells (ID 2947, 2952, 2975) (further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [J] . EFSA Journal . 2012,第8期

机译：关于证实嗜酸乳杆菌BCCM / LMG P-18806，德氏乳杆菌BCCM / LMG P-18805和嗜热链球菌BCCM / LMG P-18807并降低胃肠道不适感的健康主张的科学意见（ID 2946， 2951、2974），减少潜在致病性的胃肠道微生物（ID 2946、2951、2974），改善乳糖消化（ID 2946、2951、2974）和减少循环中CD34 +细胞的数量（ID 2947、2952、2975）（（第1924/2006号法规（EC）第13（1）条）
3. Scientific Opinion on the substantiation of health claims related to fructooligosaccharides (FOS) from sucrose and decreasing potentially pathogenic gastro intestinal microorganisms (ID 774), changes in short chain fatty acid (SCFA) production and pH in the gastro‐intestinal tract (ID 775), changes in bowel function (ID 775, 778), reduction of gastro intestinal discomfort (ID 775, 778), increase in calcium and/or magnesium absorption leading to an increase in magnesium and/or calcium retention (ID 776, 777), maintenance of normal blood LDL cholesterol concentrations (ID 805) and maintenance of normal (fasting) blood concentrations of triglycerides (ID 805) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [J] . EFSA Journal . 2011,第4期

机译：关于证实来自蔗糖的低聚果糖（FOS）和减少潜在致病性胃肠道微生物（ID 774），短链脂肪酸（SCFA）产量和胃肠道pH（ID 775）变化的健康主张的科学意见，肠功能的改变（ID 775、778），肠胃不适的减轻（ID 775、778），钙和/或镁吸收的增加导致镁和/或钙retention留的增加（ID 776、777），根据法规（EC）第1924/2006号第13（1）条，维持正常血液LDL胆固醇浓度（ID 805）和维持正常（禁食）甘油三酸酯浓度（ID 805）
4. Scientific Opinion on the substantiation of health claims related to various microorganisms and reduction of gastro-intestinal discomfort (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970), decreasing potentially pathogenic gastro-intestinal microorganisms (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970), improved lactose digestion (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970), “intestinal flora/digestive health” (ID 4231), defence against vaginal pathogens (ID 2950, 2957, 2967) and increasing IL-10 production and/or enhancing the activity of natural killer cells (ID 2960, 2962, 2971) (further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [O] . EFSA Panel on Dietetic Products, Nutrition and Allergies 2012

机译：关于证实与各种微生物有关的健康主张并减少肠胃不适的科学意见（ID 1030、2956、2958、2961、2963、2966、2970），减少了潜在致病性的肠胃微生物（ID 1030、2956、2958），2961、2963、2966、2970），改善的乳糖消化（ID 1030、2956、2958、2961、2963、2966、2970），“肠道菌群/消化系统健康”（ID 4231），防御阴道病原体（ID 2950， 2957、2967）和增加IL-10的产生和/或增强自然杀伤细胞的活性（ID 2960、2962、2971）（进一步评估），依据法规（EC）1924/2006第13（1）条

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